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Multiple Sclerosis
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Primary progressive multiple sclerosis: a comparative study of the diagnostic criteria

J. de Seze

Department of Neurology, Hôpital Civil, Strasbourg, France, jerome.de.seze{at}chru-strasbourg.fr

M. Debouverie

Department of Neurology, Hôpital Universitaire, Nancy, France

N. Waucquier

Department of Neurology, Hôpital Salengro, Lille, France

G. Steinmetz

Department of Neurology, Hôpital Civil, Strasbourg, France

S. Pittion

Department of Neurology, Hôpital Universitaire, Nancy, France

H. Zephir

Department of Neurology, Hôpital Salengro, Lille, France

M. Fleury

Department of Neurology, Hôpital Civil, Strasbourg, France

F. Blanc

Department of Neurology, Hôpital Civil, Strasbourg, France

P. Vermersch

Department of Neurology, Hôpital Salengro, Lille, France

We assessed the different sets of diagnostic criteria for primary progressive multiple sclerosis (PPMS), in order to determine their sensitivity when applied to a cohort of 261 PPMS patients. According to the Thompson criteria, 168 patients (64.4%) had definite PPMS, 84 patients (32.2%) had probable PPMS, and nine patients (3.4%) had possible PPMS; according to the McDonald criteria, 180 patients (69%) had PPMS; according to the revised McDonald criteria, 194 patients (74.3%) had PPMS. Our findings indicate that the revised McDonald criteria are more sensitive than the original McDonald criteria, but less sensitive than the Thompson criteria. Multiple Sclerosis 2007; 13: 622-625. http://msj.sagepub.com

Key Words: multiple sclerosis • criteria • MRI • pensidiagnosis

This version was published on June 1, 2007

Multiple Sclerosis, Vol. 13, No. 5, 622-625 (2007)
DOI: 10.1177/1352458506071767
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