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Impact of fatigue in multiple sclerosis: the Fatigue Impact Scale for Daily Use (D-FIS)

Department of Neurology, Móstoles General Hospital, Madrid, Spain, jbenitol{at}meditex.es

P. Martínez-Martín

Unit of Neuroepidemiology, National Centre for Epidemiology, ISC, The Spanish Network HOHSR, Madrid, Spain

B. Frades

Unit of Neuroepidemiology, National Centre for Epidemiology, ISC, The Spanish Network HOHSR, Madrid, Spain

M.L. Martínez-Ginés

Department of Neurology, Gregorio Marañón University Teaching Hospital, Madrid, Spain

C. de Andrés

Department of Neurology, Gregorio Marañón University Teaching Hospital, Madrid, Spain

J.E. Meca-Lallana

Department of Neurology, Virgen de la Arrixaca University Teaching Hospital, Murcia, Spain

A.R. Antigüedad

Department of Neurology, Basurto Hospital, Bilbao, Spain

B. Huete-Antón

Department of Neurology, Basurto Hospital, Bilbao, Spain

E. Rodríguez-García

Department of Neurology, Severo Ochoa Hospital, Leganés, Madrid, Spain

J. Ruiz-Martínez

Department of Neurology, Mendaro Hospital, Guipúzcoa, Spain

Objective The Fatigue Impact Scale for Daily Use (D-FIS) is an eight-item instrument designed to measure subjective daily experience of fatigue. This study sought to determine the metric properties of the D-FIS in multiple sclerosis (MS) patients.

Methods Sixty-eight patients with operationally-defined MS and fatigue (54.8% of the sample) underwent the D-FIS. Usual clinical measures for MS, the Montgomery-Asberg Depression Rating Scale (MADRS) and the Functional Assessment of Multiple Sclerosis (FAMS) were also applied. In addition, patients with fatigue completed the Fatigue Descriptive Scale, the Multidimensional Fatigue Inventory (MFI), a Visual Analogue Scale for Fatigue (VAS-F), and a Global Perception of Fatigue Scale (GPF).

Results Full computable data, 95.6%; both floor and ceiling effect=1.54%; item-total correlation =0.62 (item 1) to 0.84 (item 6); Cronbach's alpha =0.91; item homogeneity =0.55; standard error of measurement =3.18; convergent validity with other fatigue measures = -0.57 (VAS-F); 0.52 (GPF); and 0.46 (MFI-general fatigue). Test-retest reliability (ICC) =0.81. There was a strong association between health-related quality of life (HRQoL) (FAMS) and D-FIS (r_S=0.70).

Conclusions In this study, D-FIS proved to be a feasible and valid instrument for measuring MSrelated fatigue, a frequent symptom associated with deterioration of patients' HRQoL. Multiple Sclerosis 2007; 13: 645-651. http://msj.sagepub.com

Key Words: assessment • D-FIS • fatigue • multiple sclerosis • psychometric attributes • quality of life

This version was published on June 1, 2007

Multiple Sclerosis, Vol. 13, No. 5, 645-651 (2007)
DOI: 10.1177/1352458506073528


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