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Multiple Sclerosis
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What's this?

Autologous hematopoietic stem cell transplantation for very active relapsing-remitting multiple sclerosis: report of two cases

E. Portaccio

Department of Neurology, University of Florence, Florence, Italy, portilio{at}tin.it

M.P. Amato

Department of Neurology, University of Florence, Florence, Italy

G. Siracusa

Department of Neurology, University of Florence, Florence, Italy

F. Pagliai

Bone Marrow Transplantation Unit, Careggi Hospital, Florence, Italy

S. Sorbi

Department of Neurology, University of Florence, Florence, Italy

S. Guidi

Bone Marrow Transplantation Unit, Careggi Hospital, Florence, Italy

A. Bosi

Bone Marrow Transplantation Unit, Careggi Hospital, Florence, Italy

R. Saccardi

Bone Marrow Transplantation Unit, Careggi Hospital, Florence, Italy

Autologous hematopoietic stem cell transplantation (AHSCT) has been proposed as a rescue treatment in multiple sclerosis (MS) patients not responding to first- or second-line therapies. To date, most of the treated cases had a secondary progressive disease course. However, patients with high inflammatory activity, but no secondary progression of the disease, could be candidates to take greater advantage of AHSCT. In this paper, we report two cases with very active, relapsing-remitting (RR) MS, who underwent AHSCT, and obtained a dramatic resolution to disease activity. Multiple Sclerosis 2007; 13: 676-678. http://msj.sagepub.com

Key Words: autologous stem cell transplantation • multiple sclerosis

This version was published on June 1, 2007

Multiple Sclerosis, Vol. 13, No. 5, 676-678 (2007)
DOI: 10.1177/1352458506073502
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This article has been cited by other articles:


Home page
 Mult SclerHome page
J Fagius, J Lundgren, and G Oberg
Early highly aggressive MS successfully treated by hematopoietic stem cell transplantation
Multiple Sclerosis, February 1, 2009; 15(2): 229 - 237.
[Abstract] [PDF]


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