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This version was published on July 1, 2007
Multiple Sclerosis, Vol. 13, No. 6, 814-816 (2007)
DOI: 10.1177/1352458506075261

Bilateral trigeminal enhancement on magnetic resonance imaging in a patient with multiple sclerosis and trigeminal neuralgia

A. Pichiecchio

Neuroradiology Unit, Neurological Institute IRCCS 'Fondazione C. Mondino', 27100 Pavia, Italy, anna.pichiecchio{at}mondino.it

R. Bergamaschi

Multiple Sclerosis Centre, Neurological Institute IRCCS 'Fondazione C. Mondino', 27100 Pavia, Italy

E. Tavazzi

Multiple Sclerosis Centre, Neurological Institute IRCCS 'Fondazione C. Mondino', 27100 Pavia, Italy

A. Romani

Multiple Sclerosis Centre, Neurological Institute IRCCS 'Fondazione C. Mondino', 27100 Pavia, Italy

A. Todeschini

Neuroradiology Department, Policlinico di Modena, 41100 Modena, Italy

S. Bastianello

Neuroradiology Unit, Neurological Institute IRCCS 'Fondazione C. Mondino', 27100 Pavia, Italy

We report on clinical and instrumental findings of a multiple sclerosis (MS) patient with sudden right trigeminal neuralgia (TN). Magnetic resonance imaging (MRI), performed at TN onset, showed enlargement of both trigeminal nerves (TrN) at the root entry zone, with gadolinium enhancement of the cisternal portion. This is the first description of clinical and MRI findings indicative of peripheral involvement of the fifth cranial nerve in a MS patient complaining of TN. Our report shows the concomitant involvement of central and peripheral myelin in MS, and adds further highlights to the question regarding peripheral nerve involvement abnormalities associated with a disease considered limited to the central nervous system (CNS). Multiple Sclerosis 2007; 13: 814-816. http://msj.sagepub.com

Key Words: magnetic resonance imaging • multiple sclerosis • trigeminal enhancement • trigeminal neuralgia


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