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Quantification of subtle blood-brain barrier disruption in non-enhancing lesions in multiple sclerosis: a study of disease and lesion subtypesNMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK, d.miller{at}ion.ucl.ac.uk
Few attempts have been made to detect subtle blood-brain barrier (BBB) leakage in visibly non-enhancing MRI lesions in multiple sclerosis (MS). For 19 patients, longitudinal relaxation time (T1) maps were generated from MRI scans obtained before, and at 20, 40 and 60 minutes after injection of gadolinium (Gd)-DTPA (0.3 mmol/kg). Regions of interest (ROI) were placed around non-enhancing lesions, and in paired contralateral normal appearing brain tissue (NABT). Post-Gd rate of R1 (=1/T1) rise (
Key Words: blood brain barrier multiple sclerosis non-enhancing lesions T1 maps
This version was published on August
1, 2007 Multiple Sclerosis, Vol. 13, No. 7,
884-894 (2007) |
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R1/
0.001 at all post-Gd timepoints).