This Article Full Text (PDF) All Versions of this Article: 1352458507077864v1 13/8/1046    most recent References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (4) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Cetin, K. Articles by Kraft, G.H. Search for Related Content PubMed PubMed Citation Articles by Cetin, K. Articles by Kraft, G.H. Social Bookmarking                         What's this?

Antidepressant use in multiple sclerosis: epidemiologic study of a large community sample

Department of Rehabilitation Medicine, School of Medicine, University of Washington Box 356490, Seattle, WA 98195, USA

K.L. Johnson

Department of Rehabilitation Medicine, School of Medicine, University of Washington Box 356490, Seattle, WA 98195, USA, kjohnson{at}u.washington.edu

D.M. Ehde

Department of Rehabilitation Medicine, School of Medicine, University of Washington Box 356490, Seattle, WA 98195, USA

C.M. Kuehn

Department of Rehabilitation Medicine, School of Medicine, University of Washington Box 356490, Seattle, WA 98195, USA

D. Amtmann

Department of Rehabilitation Medicine, School of Medicine, University of Washington Box 356490, Seattle, WA 98195, USA

G.H. Kraft

Department of Rehabilitation Medicine, School of Medicine, University of Washington Box 356490, Seattle, WA 98195, USA

Depressive symptoms and disorders among individuals with multiple sclerosis (MS) are more common when compared to other chronic illnesses and the general population, but relatively little is known about the use of antidepressant medication in this population. In this cross-sectional study of 542 community-dwelling adults with MS, we examined the prevalence of antidepressant use and employed multivariate logistic regression modeling to identify factors significantly associated with antidepressant use. Thirty-five percent of the sample reported currently using at least one antidepressant medication. Gender, marital status, insurance status, fatigue, and use of disease modifying therapies were all significantly associated with antidepressant use. Just over half of the sample endorsed a clinically significant level of depressive symptoms, and the majority of this group was not currently taking an antidepressant. Conversely, 41% of those with depressive symptoms reported taking at least one antidepressant medication. More research is needed to better understand why people with MS and depressive symptoms use or do not use antidepressant medications and to further explore the possibility of an under-treatment of depressive disorder in this population. Rigorous studies testing the feasibility, acceptability, and efficacy of currently available therapies for depression in the MS population should also be conducted. Multiple Sclerosis 2007; 13: 1046—1053. http://msj.sagepub.com

Key Words: antidepressant drugs • depression • multiple sclerosis • predictors of antidepressant use

This version was published on September 1, 2007

Multiple Sclerosis, Vol. 13, No. 8, 1046-1053 (2007)
DOI: 10.1177/1352458507077864


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				G. Kraft, K. Johnson, K Yorkston, D Amtmann, A Bamer, C Bombardier, D Ehde, R Fraser, and H Starks Setting the agenda for multiple sclerosis rehabilitation research Multiple Sclerosis, November 1, 2008; 14(9): 1292 - 1297. [Abstract] [PDF]