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The long-term effect of AHSCT on MRI measures of MS evolution: a five-year follow-up study

Department of Neuroscience, Ophtalmology and Genetics, University of Genoa, Genoa

MA Rocca

Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University San Raffaele, Milan

P. Valsasina

Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University San Raffaele, Milan

L. Bonzano

Department of Neuroscience, Ophtalmology and Genetics, University of Genoa, Genoa

MP Sormani

Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University San Raffaele, Milan, Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa

R. Saccardi

Bone Marrow Transplantation Unit, University of Florence, Florence, Italy

GL Mancardi

Department of Neuroscience, Ophtalmology and Genetics, University of Genoa, Genoa

M. Filippi

Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University San Raffaele, Milan, filippi.massimo{at}hsr.it

for the Italian GITMO-NEURO Intergroup on Autologous Stem Cell Transplantation

Using MRI, we measured disease activity and brain atrophy in nine multiple sclerosis patients treated with autologous hematopoietic stem cell transplantation (AHSCT) for a mean follow up of 63 months. We show that AHSCT is associated to a longlasting suppression of inflammation and to a marked decrease of the rate of brain atrophy after the second year following treatment. Multiple Sclerosis 2007; 13 : 1068—1070. http://msj.sagepub.com

Key Words: atrophy • autologous hematopoietic stem cell transplantation • magnetic resonance imaging • multiple sclerosis

This version was published on September 1, 2007

Multiple Sclerosis, Vol. 13, No. 8, 1068-1070 (2007)
DOI: 10.1177/1352458507076982


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