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Multidisciplinary fatigue management programme in multiple sclerosis: a randomized clinical trial

Department of Rehabilitation Research, Vrije Universiteit Brussel, Brussels, Belgium, Department of Occupational Therapy, National MS Centre, Melsbroek, Belgium, Daphne.Kos{at}vub.ac.be

M. Duportail

Department of Occupational Therapy, National MS Centre, Melsbroek, Belgium

MB D'hooghe

Department of Neurology, National MS Centre, Melsbroek, Belgium

G. Nagels

Department of Neurology, National MS Centre, Melsbroek, Belgium

E. Kerckhofs

Department of Neurological Rehabilitation, Vrije Universiteit Brussel, Brussels, Belgium

Objective To establish the efficacy of a multidisciplinary fatigue management programme (MFMP) in MS.

Method Fifty-one subjects with MS were randomly allocated to group A, who only received the four weeks MFMP, or group B receiving a placebo intervention programme first and the MFMP after 6 months. In both groups, assessment was performed at baseline, 3 weeks and 6 months after the programmes and included Modified Fatigue Impact Scale (MFIS), Fatigue Severity Scale (FSS), MS Self-Efficacy scale (MSSE), Mental Health Inventory (MHI) and Impact on Participation and Autonomy (IPA).

Results The MFIS showed a significant change over time (F(4,152) = 3.346, P = 0.012), which was similar in both groups (time*group interaction: F(4,152) = 1.094, P = 0.361). A clinically relevant reduction of MFIS score of 10 points or more was found in 17% of individuals following the MFMP, compared to 44% after the placebo intervention programme (P = 0.06). Compared to no intervention, a significant effect of the MFMP after 6 months (P = 0.003) was found in five participants (31%). No significant changes in FSS, MSSE, MHI and IPA, in both groups, were found.

Conclusion Although an additional effect was found, the multidisciplinary fatigue management programme showed no efficacy in reducing the impact of fatigue compared to a placebo intervention programme. Multiple Sclerosis 2007; 13: 996—1003. http://msj.sagepub.com

Key Words: education • energy management • fatigue management programme • modified fatigue impact scale • multidisciplinary • self-care

This version was published on September 1, 2007

Multiple Sclerosis, Vol. 13, No. 8, 996-1003 (2007)
DOI: 10.1177/1352458507078392


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