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1352458508089687v1
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First published on June 23, 2008, doi:10.1177/1352458508089687

Multiple Sclerosis 2008;14:857.

A more recent version of this article appeared on July 1, 2008

Article

Interferon {beta} therapy increases serum ferritin levels in patients with relapsing-remitting multiple sclerosis

A Sena1, R Pedrosa2, V Ferret-Sena3, M J Cascais4, R Roque2, C Araújo2, and R Couderc5

1 Departamento de Bioquimica, Faculdade de Ciencias Médicas, Lisbon, Portugal; Service de Neurologia, Hospital dos Capuchos, Lisboa, Portugal
2 Service de Neurologia, Hospital dos Capuchos, Lisboa, Portugal
3 Departmento de Fisiologia, Cooperative Egas Moniz, Monte da Caparica, Portugal
4 Departamento de Bioquimica, Faculdade de Ciêrcias Médicas, Lisbon, Portugal
5 Laboratoire de Biochimie, Hôpital Trousseau AP-HP, Paris, France

* To whom correspondence should be addressed.


  Abstract

Serum ferritin levels have been found to be increased in patients with active progressive multiple sclerosis (MS). However, its levels are reported to be unchanged in stable and in active relapsing-remitting (RR) form of the disease. No research to date has assessed the influence of interferon {beta} (IFN-{beta}) on ferritin concentrations. In this study, serum ferritin levels were measured in 43 individuals with RR-MS and 38 age- and sex-matched control volunteers. There were no significant differences between controls and patients under stable and untreated conditions. In patients at 12 months after the beginning of IFN-{beta} therapy, ferritin levels were higher in women and in men, in comparison with baseline (71.4 ± 58.6 vs 43.4 ± 29.9 ng/mL, P = 0.0006 and 216.0 ± 124.3 vs 127.8 ± 74.9 ng/mL, P = 0.0022, respectively). These results suggest that larger prospective studies are required to evaluate the role of serum ferritin in MS and its potential usefulness in monitoring responses to immunomodulatory therapies.

Key Words: multiple sclerosis, ferritin, iron metabolism, interferon beta


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