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First published on June 23, 2008, doi:10.1177/1352458508092353

Multiple Sclerosis 2008;14:1120.

A more recent version of this article appeared on September 1, 2008

Article

EBNA-1 reactivity and HLA DRB1*1501 as statistically independent risk factors for multiple sclerosis: a case-control study

P Sundström1*, L Nyström2, E Jidell3, and G Hallmans4

1 Department of Neurology, Umeå University Hospital, Umea, Sweden
2 Department of Public Health and Clinical Medicine, Epidemiology and Public Health Sciences, Umeå University, Umea, Sweden
3 Department of Transfusion Medicine, Umeå University Hospital, Umea, Sweden
4 Department of Public Health and Clinical Medicine, Nutritional Research, Umea University, Umea, Sweden

* To whom correspondence should be addressed.


  Abstract

Objectives and methods

The interaction between the two best documented risk factors (human leukocyte antigen [HLA] class II [DRB1*1501 positivity] and Epstein-Barr virus [elevated Epstein-Barr nuclear antigen 1 (EBNA-1) antibody reactivity]) for multiple sclerosis (MS) was studied in a case-control study of biobank samples from 109 MS cases and 212 matched referents.

Results

Multivariate logistic regression analysis showed that both were statistically significant in both sexes. HLA DRB1*1501-positive referents had higher EBNA-1 reactivity than HLA-negative referents. Less EBNA-1 reactivity was required to increase the MS risk in HLA DRB1*1501-positives than in HLA-negatives.

Conclusion

We suggest that HLA DRB1*1501-positive individuals have an increased vulnerability to EBV-induced autoimmunity.

Key Words: EBNA-1, epstein-barr virus, HLA DRB1*1501, multiple sclerosis


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