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Multiple Sclerosis
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Multiple sclerosis and the CTLA4 autoimmunity polymorphism CT60: no association in patients from Germany, Hungary and Poland

Bernhard Greve

Department of General Neurology, Hertie Institute for Clinical Brain Research, Tübingen, Germany, bernhard.greve{at}uni-tuebingen.de

Rostislav Simonenko

Department of General Neurology, Hertie Institute for Clinical Brain Research, Tübingen, Germany

Zsolt Illes

Department of Neurology, University of Pecs, Hungary

Agnes Peterfalvi

Department of Neurology, University of Pecs, Hungary

Nada Hamdi

Department of General Neurology, Hertie Institute for Clinical Brain Research, Tübingen, Germany

Marcin P Mycko

Department of Neurology, Laboratory of Neuroimmunology, Medical University of Lodz, Poland

Krzysztof W Selmaj

Department of Neurology, Laboratory of Neuroimmunology, Medical University of Lodz, Poland

Csilla Rozsa

Department of Neurology, Jahn Ferenc Teaching Hospital, Budapest, Hungary

Katalin Rajczy

Department of Immunogenetics, National Medical Center, Budapest, Hungary

Peter Bauer

Institute of Anthropology and Human Genetics, University of Tübingen, Germany

Klaus Berger

Institute of Epidemiology and Social Medicine, University of Münster, Germany

Robert Weissert

Department of General Neurology, Hertie Institute for Clinical Brain Research, Tübingen, Germany

Polymorphisms in the CTLA4 gene region have been associated with susceptibility to autoimmune diseases. The recently described single nucleotide polymorphism CT60, located in the 3' untranslated region of CTLA4 is associated with Graves' disease, thyroiditis, autoimmune diabetes and other autoimmune diseases. A case-control association study was conducted in German, Hungarian and Polish multiple sclerosis (MS) patients and regional control individuals for the CTLA4 CT60 and +49A/G polymorphisms. No significant association of these polymorphisms or respective haplotypes with MS was found. No association of CT60 genotypes with T cell expression of ICOS and CTLA-4 after in vitro stimulation was detected. Multiple Sclerosis 2008; 14: 153—158. http://msj.sagepub.com

Key Words: association • CTLA-4 • genetics • multiple sclerosis • polymorphism

This version was published on March 1, 2008

Multiple Sclerosis, Vol. 14, No. 2, 153-158 (2008)
DOI: 10.1177/1352458507082357
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