This Article Full Text (PDF) All Versions of this Article: 1352458507081343v1 14/2/177    most recent References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Woolmore, J. Articles by Hawkins, C. Search for Related Content PubMed PubMed Citation Articles by Woolmore, J. Articles by Hawkins, C. Social Bookmarking                         What's this?

Polymorphisms of the cannabinoid 1 receptor gene and cognitive impairment in multiple sclerosis

Institute of Science and Technology in Medicine, Keele University Medical School, Hartshill Campus, University Hospital of North Staffordshire, Stoke on Trent, Staffordshire ST4 7LN, UK, john.woolmore{at}yahoo.com

MJ Stone

Institute of Science and Technology in Medicine, Keele University Medical School, Hartshill Campus, University Hospital of North Staffordshire, Stoke on Trent, Staffordshire ST4 7LN, UK

SL Holley

Institute of Science and Technology in Medicine, Keele University Medical School, Hartshill Campus, University Hospital of North Staffordshire, Stoke on Trent, Staffordshire ST4 7LN, UK

PM Jenkinson

School of Psychology, Keele Universtity, Keele, Staffordshire ST5 5BG, UK

A. Ike

Institute of Science and Technology in Medicine, Keele University Medical School, Hartshill Campus, University Hospital of North Staffordshire, Stoke on Trent, Staffordshire ST4 7LN, UK

PW Jones

School of Computing and Mathematics, Keele University, Keele, Staffordshire ST5 5BG, UK

AA Fryer

Institute of Science and Technology in Medicine, Keele University Medical School, Hartshill Campus, University Hospital of North Staffordshire, Stoke on Trent, Staffordshire ST4 7LN, UK

RC Strange

Institute of Science and Technology in Medicine, Keele University Medical School, Hartshill Campus, University Hospital of North Staffordshire, Stoke on Trent, Staffordshire ST4 7LN, UK

R. Stephens

School of Psychology, Keele Universtity, Keele, Staffordshire ST5 5BG, UK

DW Langdon

Department of Psychology, Royal Holloway, University of London, London TW20 0EX, UK

CP Hawkins

Institute of Science and Technology in Medicine, Keele University Medical School, Hartshill Campus, University Hospital of North Staffordshire, Stoke on Trent, Staffordshire ST4 7LN, UK

Cognitive impairment occurs in 45—65% of multiple sclerosis (MS) patients. The cannabinoid system may potentially be neuroprotective in MS. We examined the relationship between polymorphisms of the CNR1 gene and neuropsychological outcome in MS using a test and confirmatory sample of patients. One hundred and ninety-four MS patients were assessed over five key areas of neuropsychological function, which are most commonly impaired in MS. The first 97 patients formed the test sample. A further confirmatory sample of 97 patients was used to test association found in the test sample. The schedule included: Wisconsin card sorting test 64 version, Rey auditory verbal learning task immediate and delayed scores, controlled oral word association task, judgement of line orientation and symbol digit modalities task. Three single nucleotide polymorphisms (SNPs) were typed within the CNR1 gene.

For the overall neuropsychological assessment score we used a multiple linear regression model with selected covariates to show that subjects with the AA genotype of the SNP RS1049353 were more impaired (mean -2.47, SD 5.75, P = 0.008, Bonferroni corrected P = 0.024) than the other subjects (mean 0.24, SD 4.24). This was not confirmed when the association was retested in the confirmatory sample.

No associations were identified between these CNR1 variants and cognitive impairment in MS. Multiple Sclerosis 2008; 14: 177—182. http://msj.sagepub.com

Key Words: cannabinoid receptor • disease progression • genetic • multiple sclerosis • neuropsychology • polymorphisms

This version was published on March 1, 2008

Multiple Sclerosis, Vol. 14, No. 2, 177-182 (2008)
DOI: 10.1177/1352458507081343


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				E. Ramil, A. Sanchez, P. Gonzalez-Perez, A. Rodriguez-Antiguedad, N. Gomez-Lozano, P. Ortiz, R. Arroyo, V. De las Heras, C. Vilches, and A. Garcia-Merino The cannabinoid receptor 1 gene (CNR1) and multiple sclerosis: an association study in two case-control groups from Spain Multiple Sclerosis, February 1, 2010; 16(2): 139 - 146. [Abstract] [PDF]