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Multiple Sclerosis
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Widespread maculopapular rash due to intramuscular interferon beta-1a during the treatment of multiple sclerosis

G. Serarslan

Department of Dermatology, Mustafa Kemal University, Faculty of Medicine, Antakya, Turkey, gserarslan{at}hotmail.com

EE Okuyucu

Department of Neurology, Mustafa Kemal University, Faculty of Medicine, Antakya, Turkey

IM Melek

Department of Neurology, Mustafa Kemal University, Faculty of Medicine, Antakya, Turkey

S. Hakverdi

Department of Pathology, Mustafa Kemal University, Faculty of Medicine, Antakya, Turkey

T. Duman

Department of Neurology, Mustafa Kemal University, Faculty of Medicine, Antakya, Turkey

We describe a 41-year-old woman with multiple sclerosis, who presented erythematous maculopapular rash on the trunk and extremities after the second injection of interferon beta-1a. Histopathologic examination of the lesion revealed lymphocytic exocytosis and perivascular lymphocytic infiltrate in the dermis. Oral antihistamine and topical corticosteroid was started. After improvement of the lesions, the third injection was performed. However, the same reaction occurred. A prick test, which was performed 6 weeks after the eruption, also revealed positive reaction. Although injection-site reactions have been observed with interferon beta-1a, to our knowledge there have been no previous reports of interferon beta-1a-induced widespread cutaneous reaction. Multiple Sclerosis 2008; 14: 259—261. http://msj.sagepub.com

Key Words: adverse reaction • cutaneous • interferon beta-1a • maculopapular rash • multiple sclerosis

Multiple Sclerosis, Vol. 14, No. 2, 259-261 (2008)
DOI: 10.1177/1352458507079945
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