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Multiple Sclerosis
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Chronic myeloid leukemia associated with mitoxantrone treatment in a patient with MS

Saud A. Sadiq

Division of Hematology/Oncology, Department of Medicine, St. Luke's - Roosevelt Hospital, New York, N.Y., ssadiq{at}msrcny.org

Mustapha Rammal

Division of Hematology/Oncology, Department of Medicine, St. Luke's - Roosevelt Hospital, New York, N.Y.

Gabriel Sara

Division of Hematology/Oncology, Department of Medicine, St. Luke's - Roosevelt Hospital, New York, N.Y.

We report the first case of chronic myeloid leukemia (CML) in a patient with multiple sclerosis (MS) diagnosed within two years of receiving mitoxantrone therapy. Previously only acute forms of leukemia particularly acute promyelocytic leukemia (APL) have been associated with mitoxantrone treatment in MS. This underscores the need for only using mitoxantrone in severe treatment-unresponsive cases of MS. Multiple Sclerosis 2008; 14: 272—273. http://msj.sagepub.com

Key Words: chronic myeloid leukemia • multiple sclerosis • mitoxantrone

This version was published on March 1, 2008

Multiple Sclerosis, Vol. 14, No. 2, 272-273 (2008)
DOI: 10.1177/1352458507082941
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A. M Pascual, N. Tellez, I. Bosca, J. Mallada, A. Belenguer, I. Abellan, A. P Sempere, P. Fernandez, M. J. Magraner, F. Coret, et al.
Revision of the risk of secondary leukaemia after mitoxantrone in multiple sclerosis populations is required
Multiple Sclerosis, November 1, 2009; 15(11): 1303 - 1310.
[Abstract] [PDF]


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