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Evidence for association of chromosome 10 open reading frame (C10orf27) gene polymorphisms and multiple sclerosis

Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d'Hebron (HUVH), 08035 Barcelona, Spain, robert.goertsches{at}med.uni-rostock.de

Sergio E Baranzini

Department of Neurology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143-0435, USA

Carlos Morcillo

Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain

Carlos Nos

Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d'Hebron (HUVH), 08035 Barcelona, Spain

Montse Camiña

Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d'Hebron (HUVH), 08035 Barcelona, Spain

Jorge R Oksenberg

Department of Neurology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143-0435, USA

Xavier Montalban

Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d'Hebron (HUVH), 08035 Barcelona, Spain

Manuel Comabella

Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d'Hebron (HUVH), 08035 Barcelona, Spain

A recent association study has provided evidence that chromosome 10q22.1 may contain candidate genes for multiple sclerosis (MS). We analysed two intronic and a non-synonymous single nucleotide polymorphism (SNP) of the C10orf27 gene in 571 patients with MS (relapsing remitting and primary progressive) and healthy controls. Adjusted comparisons revealed significant association with disease susceptibility for one intronic SNP in RRMS individuals and the amino acid modifying SNP for PPMS cases; the latter may also contribute to faster disease progression. Transcript expression in brain lesions from MS patients was increased. These findings suggest C10orf27 as a candidate gene for MS susceptibility and pathogenesis. Multiple selerosis 2008; 14: 412—414. http://msj.sagepub.com

Key Words: polymorphism • multiple sclerosis • open reading frame

This version was published on April 1, 2008

Multiple Sclerosis, Vol. 14, No. 3, 412-414 (2008)
DOI: 10.1177/1352458507083780


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