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This version was published on April 1, 2008
Multiple Sclerosis, Vol. 14, No. 3, 418-424 (2008)
DOI: 10.1177/1352458507084036

Baló's disease showing benign clinical course and co-existence with multiple sclerosis-like lesions in Chinese

Chaodong Wang

Department of Neurology, Jiangxi Provincial People's Hospital, Nanchang 330006, P. R. China

Kun-Nan Zhang

Department of Neurology, Jiangxi Provincial People's Hospital, Nanchang 330006, P. R. China

Xiao-Mu Wu

Department of Neurology, Jiangxi Provincial People's Hospital, Nanchang 330006, P. R. China, xmwu2007{at}yahoo.com.cn

Gang Huang

Department of Neurology, Jiangxi Provincial People's Hospital, Nanchang 330006, P. R. China

Xu-Fang Xie

Department of Neurology, Jiangxi Provincial People's Hospital, Nanchang 330006, P. R. China

Xin-Hui Qu

Department of Neurology, Jiangxi Provincial People's Hospital, Nanchang 330006, P. R. China

Ying-Qiong Xiong

Department of Neurology, Jiangxi Provincial People's Hospital, Nanchang 330006, P. R. China

Baló's concentric sclerosis (BCS) is a rare demyelinating disorder usually considered a variant of multiple sclerosis (MS). However, its pathogenesis and its correlation with MS remains unclear and controversial. This report presents seven Hans Chinese subjects diagnosed as BCS on the basis of the pathognomonic MR (magnetic resonance) findings. Upon diagnosis, all the cases displayed good responses to corticosteroids and showed an overall benign prognosis during a follow-up period of 4—13.5 years, although three relapsed later. MR findings suggest that the characteristic concentric lesions of BCS frequently (5/7) coexist with multiple sclerosis-like lesions. During follow-up, the Baló-like lesions may either dissolve over time or transform into an MS-like lesion. Moreover, the Balóand MS-like lesions occurred one after another at the onset and relapse phases of the same patient in two cases. These clinical features suggest that Baló's disease showing benign clinical course and co-existence of multiple sclerosis (MS)-like lesion is not rare among the Chinese, and strengthens the notion that BCS correlates intrinsically with MS. Multiple Sclerosis 2008; 14: 418—424. http://msj.sagepub.com

Key Words: Baló's concentric sclerosis (BCS) • magnetic resonance imaging (MRI) • multiple sclerosis (MS)


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