This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Duncan, I. Articles by Reingold, S. Search for Related Content PubMed PubMed Citation Articles by Duncan, I. Articles by Reingold, S. Social Bookmarking                         What's this?

Stem cell therapy in multiple sclerosis: promise and controversy

Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA

S Goldman

Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA

WB Macklin

Department of Neurosciences, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA

M Rao

Regenerative Medicine, Invitrogen Corporation, Timonium, Maryland, USA

LP Weiner

Keck School of Medicine, Department of Neurology, University of Southern California, Los Angeles, California, USA

SC Reingold

National Multiple Sclerosis Society and Scientific and Clinical Review Associates, LLC, New York City, New York, USA, scra.llc{at}earthlink.net

Stem cells offer the potential for regeneration of lost tissue in neurological disease, including multiple sclerosis (MS). Their development in vitro and their use in vivo in animal models of degenerative neurological disease and recent first efforts in human clinical trials were the topics of a recent international meeting sponsored by the Multiple Sclerosis International Federation and the National Multiple Sclerosis Society on "Stem Cells & MS: Prospects and Strategies" Participants reviewed the current state of knowledge about the potential use of stem and progenitor cells in MS and other degenerative neurological disorders and outlined a series of urgent fundamental and applied clinical research priorities that should allow the potential of regeneration of damaged tissue in MS to be assessed and pursued.

Key Words: multiple sclerosis • stem cells • therapy

Multiple Sclerosis, Vol. 14, No. 4, 541-546 (2008)
DOI: 10.1177/1352458507087324


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?