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Multiple Sclerosis
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MDC/CCL22 intrathecal levels in patients with multiple sclerosis

D. Galimberti

Department of Neurological Sciences, 'Dino Ferrari' Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy, daniela.galimberti{at}unimi.it

C. Fenoglio

Department of Neurological Sciences, 'Dino Ferrari' Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy

C. Comi

Department of Neurology, Ospedale Maggiore, University 'Amedeo Avogadro', Novara, Italy, Interdisciplinary Research Center of Autoimmune Diseases (IRCAD) and Department of Medical Sciences, 'A. Avogadro' University of Eastern Piedmont, Novara, Italy

D. Scalabrini

Department of Neurological Sciences, 'Dino Ferrari' Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy

M. De Riz

Department of Neurological Sciences, 'Dino Ferrari' Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy

M. Leone

Department of Neurology, Ospedale Maggiore, University 'Amedeo Avogadro', Novara, Italy

E. Venturelli

Department of Neurological Sciences, 'Dino Ferrari' Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy

F. Cortini

Department of Neurological Sciences, 'Dino Ferrari' Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy

M. Piola

Department of Neurological Sciences, 'Dino Ferrari' Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy

F. Monaco

Department of Neurology, Ospedale Maggiore, University 'Amedeo Avogadro', Novara, Italy, Interdisciplinary Research Center of Autoimmune Diseases (IRCAD) and Department of Medical Sciences, 'A. Avogadro' University of Eastern Piedmont, Novara, Italy

N. Bresolin

Department of Neurological Sciences, 'Dino Ferrari' Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy

E. Scarpini

Department of Neurological Sciences, 'Dino Ferrari' Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy

MDC/CCL22 has been detected in the brain of mice with experimental autoimmune encephalomyelitis. MDC/CCL22 cerebrospinal fluid levels were evaluated in 56 patients with multiple sclerosis (MS) and in 17 controls. No significant differences were found, even when stratifying patients according to the disease subtype. Stratifying by gender, significantly increased MDC/CCL22 levels were observed in female patients when compared with female controls and male patients (109.03 versus 98.54 and 99.37 pg/mL, P = 0.034 and 0.018, respectively). Therefore, MDC/CCL22 is likely to play a role in the development of MS in females only, possibly influencing the intracerebral recruitment of Th2 cells, which produce anti-inflammatory cytokines. Multiple Sclerosis 2008; 14: 547—549. http://msj.sagepub.com

Key Words: cerebrospinal fluid • MDC/CCL22 • multiple sclerosis

This version was published on May 1, 2008

Multiple Sclerosis, Vol. 14, No. 4, 547-549 (2008)
DOI: 10.1177/1352458507084268
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