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Multiple Sclerosis
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T-1237C polymorphism of TLR9 gene is not associated with multiple sclerosis in the Portuguese population

A. Carvalho

Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal

M. Santos

Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal, ICBAS, University of Porto, Porto, Portugal

P. Maciel

Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal

F. Rodrigues

Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal, frodrigues{at}ecsaude.uminho.pt

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, with disturbances of the immunological balance. As TLR9-null mice showed increased resistance to experimental autoimmune encephalomyelitis and recent genetic investigations showed that T-1237C promoter polymorphism of TLR9, commonly implicated in autoimmune diseases, induces a deregulation of its expression, we performed an association study in a Portuguese population of 165 MS patients and unrelated healthy controls. Our results show no significant association with MS and no protective effect of T-1237C concerning age of onset, disease severity or disease subtype in MS patients. Multiple Sclerosis 2008; 14 : 550—552. http://msj.sagepub.com

Key Words: disease • inflammation • innate immunity • susceptibility • toll-like receptor

This version was published on May 1, 2008

Multiple Sclerosis, Vol. 14, No. 4, 550-552 (2008)
DOI: 10.1177/1352458507084594
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