Multiple Sclerosis

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Register here to gain access to SAGE's 500+ Journals Online

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Google Scholar
Right arrow Articles by Jung, P
Right arrow Articles by Ziemann, U
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jung, P
Right arrow Articles by Ziemann, U
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Multiple Sclerosis, Vol. 14, No. 4, 553-556 (2008)
DOI: 10.1177/1352458507085758

short-report

Multimodal evoked potentials measure and predict disability progression in early relapsing–remitting multiple sclerosis

P Jung

Department of Neurology, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany, patrick.jung{at}em.uni-frankfurt.de

A Beyerle

Department of Neurology, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany

U Ziemann

Department of Neurology, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany

In 37 patients with early relapsing–remitting multiple sclerosis (RRMS), a multimodal EP score (mEPS) and clinical scores (Expanded Disability Status Scale (EDSS) and multiple sclerosis functional composite (MSFC)) were obtained prospectively over 24 months. Changes in mEPS correlated with changes in EDSS (Spearman’s {rho} = 0.69, p < 0.0001) and MSFC ({rho} = –0.41, p < 0.02). Patients with relevant EDSS progression (n = 7) showed stronger mEPS deterioration than clinically stable patients (10.8 ± 3.2 versus 1.3 ± 0.8, p < 0.005). Baseline mEPS was not significantly correlated with baseline EDSS but with EDSS after 24 months ({rho} = 0.39, p < 0.02). The data suggest that serial mEPS measure and moderately predict clinically relevant disease activity in the therapeutically most relevant early stage of RRMS.

Key Words: evoked potentials • clinical disease progression • ipsilateral silent period • multiple sclerosis functional composite


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?