This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Kawajiri, M Articles by Kira, J. Search for Related Content PubMed PubMed Citation Articles by Kawajiri, M Articles by Kira, J. Social Bookmarking                   What's this?

Reduction of angiotensin II in the cerebrospinal fluid of patients with multiple sclerosis

Department of Geriatric Medicine, Ehime University, Graduate School of Medicine, Ehime, Japan, kawajiri{at}m.ehime-u.ac.jp

M Mogi

Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Ehime, Japan

M Osoegawa

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan

T Matsuoka

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan

K Tsukuda

Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Ehime, Japan

K Kohara

Department of Geriatric Medicine, Ehime University, Graduate School of Medicine, Ehime, Japan

M Horiuchi

Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Ehime, Japan

T Miki

Department of Geriatric Medicine, Ehime University, Graduate School of Medicine, Ehime, Japan

JI Kira

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan

We previously demonstrated that angiotensin II acts as a crucial neuroprotective factor after neural injury through angiotensin II type-2 (AT2) receptor signaling. Although the pathway is known to play an important role in the development of experimental autoimmune encephalomyelitis, cerebrospinal fluid (CSF) angiotensin II levels in patients with multiple sclerosis (MS) have never been studied. To clarify the significance of angiotensin II in MS, we assayed angiotensin II concentrations using an established enzyme-linked immunoabsorbent assay in CSF samples from patients with MS (n = 21), patients with inflammatory neuropathies (IN) (n = 23) and control individuals who did not have either of the neurological diseases or any other disease that might affect the angiotensin II levels in the CSF (control) (n = 24). Angiotensin II levels in the CSF were 3.79 ± 1.54 pg/ml in the MS group, 5.13 ± 2.27 pg/ml in the IN group and 6.71 ± 2.65 pg/ml in the control group. The angiotensin II levels in the CSF of the MS group were significantly lower than in the control group (p = 0.00057). Angiotensin II concentration in the CSF tended to have a negative correlation with the Kurtzke’s Expanded Disability Status Scale scores during MS relapse (p = 0.0847). These findings suggest that reduced levels of intrathecal angiotensin II may be related to the abnormal neural damage and repair processes in MS.

Key Words: angiotensin II • multiple sclerosis • cerebrospinal fluid

Multiple Sclerosis, Vol. 14, No. 4, 557-560 (2008)
DOI: 10.1177/1352458507085760


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M Kawajiri, M Mogi, N Higaki, T Matsuoka, Y Ohyagi, K Tsukuda, K Kohara, M Horiuchi, T Miki, and J. Kira Angiotensin-converting enzyme (ACE) and ACE2 levels in the cerebrospinal fluid of patients with multiple sclerosis Multiple Sclerosis, February 1, 2009; 15(2): 262 - 265. [Abstract] [PDF]