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Multiple Sclerosis
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short-report

Molecular detection of Parachlamydia-like organisms in cerebrospinal fluid of patients with multiple sclerosis

C Contini

Section of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy, cnc{at}unife.it

S Seraceni

Section of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy

R Cultrera

Section of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy

M Castellazzi

Section of Neurology, University of Ferrara, Italy

E Granieri

Section of Neurology, University of Ferrara, Italy

E Fainardi

Section of Neurology, University of Ferrara, Italy; Neuroradiology Unit, Azienda Ospedaliera-Universitaria, Arcispedale S. Anna, Ferrara, Italy

The presence of Chlamydia-like organism DNA was investigated by polymerase chain reaction (PCR) in cerebrospinal fluid (CSF) samples from 27 patients previously found positive for Chlamydia pneumoniae DNA: 12 with multiple sclerosis (MS), grouped according to clinical and magnetic resonance imaging (MRI) evidence of disease activity, 8 with other inflammatory neurological disorders and 7 with non-inflammatory neurological disorders. PCR evidence of Chlamydia-like organisms in CSF was observed only in two relapsing–remitting MS patients with clinical and MRI disease activity. These findings suggest a possible association between C. pneumoniae and Chlamydia-like organism brain infections as a cofactor in MS development.

Key Words: Chlamydia-like organisms • cerebrospinal fluid • multiple sclerosis • polymerase chain reaction

Multiple Sclerosis, Vol. 14, No. 4, 564-566 (2008)
DOI: 10.1177/1352458507085796
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