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Multiple Sclerosis
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What's this?

case-report

The safety of baclofen in pregnancy: intrathecal therapy in multiple sclerosis

Catherine M Dalton

National Hospital for Neurology and Neurosurgery, Queen Square, London WC1 N3BG, catherine.dalton{at}uclh.nhs.uk

Elizabeth Keenan

National Hospital for Neurology and Neurosurgery, Queen Square, London WC1 N3BG

Louise Jarrett

National Hospital for Neurology and Neurosurgery, Queen Square, London WC1 N3BG

Lisa Buckley

National Hospital for Neurology and Neurosurgery, Queen Square, London WC1 N3BG

Valerie L Stevenson

National Hospital for Neurology and Neurosurgery, Queen Square, London WC1 N3BG

Intrathecal baclofen is a GABA-receptor agonist and one of the mainstay treatments of severe spasticity due to multiple sclerosis (MS). The authors report a case on the use of intrathecal baclofen administered using a Medtronic Synchromed II infusion pump. A healthy male infant (2.68 kg, Apgars 9 and 10) was born at 36 weeks gestation by cesarean section, under general anesthetic. This is the fifth reported case of intrathecal baclofen administered during pregnancy and adds to the knowledge that thus far it is relatively safe in pregnancy and may in fact be safer for the infant than oral baclofen. This is the first case report of the use of intrathecal baclofen in pregnancy and MS.

Key Words: baclofen • pregnancy • multiple sclerosis

Multiple Sclerosis, Vol. 14, No. 4, 571-572 (2008)
DOI: 10.1177/1352458507085552
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