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Multiple Sclerosis
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short-report

Midbrain lesions and paroxysmal dysarthria in multiple sclerosis

Y Blanco

Service of Neurology, Hospital Clinic, Universitat de Barcelona and IDIBAPS, Barcelona, Spain

Y Compta

Service of Neurology, Hospital Clinic, Universitat de Barcelona and IDIBAPS, Barcelona, Spain

F Graus

Service of Neurology, Hospital Clinic, Universitat de Barcelona and IDIBAPS, Barcelona, Spain

A Saiz

Service of Neurology, Hospital Clinic, Universitat de Barcelona and IDIBAPS, Barcelona, Spain, asaiz{at}clinic.ub.es

We describe three patients with relapsing–remitting multiple sclerosis who presented with paroxysmal dysarthria. In one patient, the symptoms were the only manifestation of an acute relapse. In the other two patients, the attacks appeared during the recovery of a brainstem relapse. All three patients had an acute lower midbrain lesion. The location was central in two patients and left paramedian in the other, and probably involving cerebellothalamocortical pathways. Treatment with carbamazepine was effective.

Key Words: dysarthria • magnetic resonance imaging • multiple sclerosis • paroxysmal attacks

Multiple Sclerosis, Vol. 14, No. 5, 694-697 (2008)
DOI: 10.1177/1352458507087846
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