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Multiple Sclerosis
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case-report

Apneusis responding to buspirone in multiple sclerosis

RJ O’Sullivan

Department of Neurology, Royal Brisbane and Women’s Hospital, Herston, Queensland, Australia

IG Brown

Department of Thoracic Medicine, Royal Brisbane and Women’s Hospital, Herston, Queensland, Australia

MP Pender

Department of Neurology, Royal Brisbane and Women’s Hospital, Herston, Queensland, Australia; School of Medicine, The University of Queensland, Brisbane, Queensland, Australia, m.hawes{at}uq.edu.au

Apneusis is a disturbance of respiratory rhythm characterized by severely prolonged inspiratory effort, and is caused by bilateral lesions in the dorsal pons. In humans it is most commonly caused by pontine infarction and has rarely been reported in multiple sclerosis (MS). Here we report on a patient with MS who developed episodic apneusis which responded to treatment with buspirone, a serotonin type 1A receptor agonist.

Key Words: apneusis • buspirone • hypoxia • multiple sclerosis • pons • respiratory • serotonin agonist

This version was published on June 1, 2008

Multiple Sclerosis, Vol. 14, No. 5, 705-707 (2008)
DOI: 10.1177/1352458507085802
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