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Multiple Sclerosis
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research-article

CCR5 expression on macrophages/microglia is associated with early remyelination in multiple sclerosis lesions

C Trebst

Department of Neurology, Medical School Hannover, Hannover, Germany, trebst.corinna{at}mh-hannover.de

F König

Department of Neuropathology, University Medical Center, Göttingen, Germany

RM Ransohoff

Neuroinflammation Research Center, Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

W Brück

Department of Neuropathology, University Medical Center, Göttingen, Germany

M Stangel

Department of Neurology, Medical School Hannover, Hannover, Germany

Remyelination in multiple sclerosis (MS) occurs spontaneously and extensively. The underlying mechanisms, however, are only partly understood. Findings in experimental animal settings suggest that inflammation promotes remyelination and repair. Here, we characterized the chemokine receptor expression profiles of macrophages/microglia in early remyelinating and completely remyelinated lesions compared with active demyelinating and inactive demyelinated MS lesions obtained in the early disease course. Biopsy material consisting of 16 MS cases was available for this study. We found that macrophages/microglia within early remyelinating lesions expressed predominantly CCR5. Our findings implicate a possible role of CCR5+ cells in initiating remyelination.

Key Words: chemokine receptor • macrophages • microglia • multiple sclerosis • remyelination

Multiple Sclerosis, Vol. 14, No. 6, 728-733 (2008)
DOI: 10.1177/1352458508089359
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