Multiple Sclerosis

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
1352458508088918v1
14/6/739    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Google Scholar
Right arrow Articles by Iarlori, C
Right arrow Articles by Reale, M
PubMed
Right arrow PubMed Citation
Right arrow Articles by Iarlori, C
Right arrow Articles by Reale, M
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
This version was published on July 1, 2008
Multiple Sclerosis, Vol. 14, No. 6, 739-748 (2008)
DOI: 10.1177/1352458508088918

research-article

Reduction of free radicals in multiple sclerosis: effect of glatiramer acetate (Copaxone®)

C Iarlori

Unit of Clinical Neurology, Department of Oncology and Neuroscience, University ‘G. D’Annunzio’, Chieti, Italy

D Gambi

Unit of Clinical Neurology, Department of Oncology and Neuroscience, University ‘G. D’Annunzio’, Chieti, Italy; Centre of Excellence on Aging, Chieti, Italy

A Lugaresi

Unit of Clinical Neurology, Department of Oncology and Neuroscience, University ‘G. D’Annunzio’, Chieti, Italy

A Patruno

Department of Drug Sciences, University ‘G. D’Annunzio’, Chieti, Italy

M Felaco

Department of Human Dynamics, University ‘G. D’Annunzio’, Chieti, Italy

M Salvatore

FAO, Roma, Italy

L Speranza

Department of Human Dynamics, University ‘G. D’Annunzio’, Chieti, Italy

M Reale

Unit of Immunology, Department of Oncology and Neuroscience, University ‘G. D’Annunzio’, Chieti, Italy, mreale{at}unich.it

Free radicals have been found in high concentrations within inflammatory multiple sclerosis (MS) lesions. The superoxide anion (O2–) reacts rapidly with nitric oxide (NO), producing peroxynitrite (ONOO–). Glatiramer acetate (GA) is a specific MS immunomodulator that induces the synthesis of Th2 cytokines, and reduces the frequency of relapses and the formation of active brain lesions. Proinflammatory cytokines could play a role in free radicals production in the peripheral immune system as well as in the central nervous system (CNS). The effect of GA on iNOS, superoxide radicals (O2–) and 3-nitrotyrosine production by peripheral blood adherent mononuclear cells (PBAMs) was assessed. Our findings demonstrate that in vitro GA reduced spontaneous and LPS-induced iNOS, 3-nitrotyrosine, NO and O2– production, and that similar inhibition can be demonstrated ex vivo in mononuclear cells obtained from GA-treated patients. The inhibition of the production of free radicals in PBAMs may represent a new therapeutic mechanism against inflammation during MS.

Key Words: ELISA • glatiramer acetate • inducible nitric oxide synthase • nitric oxide • peripheral blood adherent mononuclear cells • peroxynitrite • relapsing–remitting multiple sclerosis • superoxide anion • western blot


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?