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Constraint-Induced Movement therapy can improve hemiparetic progressive multiple sclerosis. Preliminary findings

Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Alabama, USA vwmark{at}uab.edu

E Taub

Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA

K Bashir

Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA

G Uswatte

Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA

A Delgado

Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA

MH Bowman

Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA

CC Bryson

Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA

S McKay

Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA

GR Cutter

Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, USA

Objective

To evaluate whether Constraint-Induced Movement therapy (CI therapy) may benefit chronic upper extremity hemiparesis in progressive multiple sclerosis (MS).

Methods

Five patients with progressive MS, who had chronic upper extremity hemiparesis and evidence for learned non-use of the paretic limb in the life situation, underwent 30 hours of repetitive task training and shaping for the paretic limb over 2–10 consecutive weeks, along with physical restraint of the less-affected arm and a "transfer package" of behavioral techniques to reinforce treatment adherence.

Results

The patients showed significantly improved spontaneous, real-world limb use at post-treatment and 4 weeks post-treatment, along with improved fatigue ratings and maximal movement ability displayed in a laboratory motor test.

Conclusions

The findings suggest for the first time that slowly progressive MS may benefit from CI therapy. Further studies are needed to determine the retention of treatment responses.

Key Words: daily living activities • motor • multiple sclerosis • neuronal plasticity • physical therapy modalities • rehabilitation

This version was published on August 1, 2008

Multiple Sclerosis, Vol. 14, No. 7, 992-994 (2008)
DOI: 10.1177/1352458508090223


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