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Correlation between DJ-1 levels in the cerebrospinal fluid and the progression of disabilities in multiple sclerosis patients

Department of Neurology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan;

C Maita

Graduate School of Agriculture, Hokkaido University, Sapporo, Japan;

M Niino

Department of Neurology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan niino{at}med.hokudai.ac.jp

SM Iguchi-Ariga

Graduate School of Agriculture, Hokkaido University, Sapporo, Japan

S Hamada

Hokuyukai Neurological Hospital, Sapporo, Japan

H Ariga

Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan

H Sasaki

Department of Neurology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan

Objectives

DJ-1 plays a key role in the anti-oxidative stress function. Increasing evidence supports the role of oxidative stress in the pathogenesis of multiple sclerosis (MS). The aim of this study was to investigate whether the DJ-1 levels were increased in patients with MS and to examine its association with the progression of MS.

Methods

Quantitative immunoblot assays were performed to evaluate the DJ-1 level in serum and cerebrospinal fluid (CSF) collected from relapsing–remitting patients with MS (n = 29), disease controls subjects (n = 14), and healthy subjects (n = 44).

Results

No significant difference was observed in the serum DJ-1 level among the patients with MS, disease controls, and healthy controls. However, the CSF DJ-1 levels were significantly higher in the patients with MS than in the disease control subjects (P < 0.0001). A significant positive correlation was also found between the CSF DJ-1 levels and the Multiple Sclerosis Severity Score (P < 0.005, r = 0.501).

Conclusions

These results show that the CSF DJ-1 levels are significantly increased in the CSF of patients with MS and that the CSF DJ-1 levels may be associated with the disease progression of MS. Therefore, DJ-1 possibly plays an important role in the pathogenesis of MS.

Key Words: cerebrospinal fluids • DJ-1 • multiple sclerosis • multiple sclerosis severity score • neurodegenerative process • oxidative stress

This version was published on September 1, 2008

Multiple Sclerosis, Vol. 14, No. 8, 1056-1060 (2008)
DOI: 10.1177/1352458508093616


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