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Relationship of cognitive impairment to psychiatric symptoms in multiple sclerosis

Section of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway nannafigved{at}gmail.com

R Benedict

The Jacobs Neurological Institute, Buffalo, New York, USA; Department of Neurology, State University of New York at Buffalo, School of Medicine and Biomedical sciences, Buffalo, New York, USA

G Klevan

Department of Neurology, Stavanger University Hospital, Stavanger, Norway

KM Myhr

Department of Neurology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, Section of Neurology, University of Bergen, Bergen, Norway

HI Nyland

Department of Neurology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, Section of Neurology, University of Bergen, Bergen, Norway

NI Landrø

Department of Psychology, University of Oslo, Oslo, Norway

JP Larsen

Norwegian Centre for Movement Disorder, Stavanger University Hospital, Stavanger, Norway; Department of Clinical Medicine, University of Bergen, Norway

D Aarsland

Section of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway; Department of Clinical Medicine, University of Bergen, Norway

Psychiatric and cognitive changes are common in patients with multiple sclerosis (MS), but their relationship has not received much attention. We studied the relationship between psychiatric symptoms and verbal memory, working memory, and mental speed in 78 patients with MS and 40 healthy control subjects using linear regression analyses. The MS group exhibited impaired performance on all cognitive tests. Apathy was associated with intrusions and depression with impaired memory and mental speed. The association between apathy and intrusions supports the hypothesis that lesions in frontal areas or frontal connections contribute to a specific neuropsychiatric syndrome in patients with MS.

Key Words: cognitive impairment • mulitple sclerosis • neuropsychiatry • neuropsychiatric symptoms

Multiple Sclerosis, Vol. 14, No. 8, 1084-1090 (2008)
DOI: 10.1177/1352458508092262


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