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Comorbidity, socioeconomic status and multiple sclerosisDepartment of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada rmarrie{at}hsc.mb.ca
Department of Medicine, Stanford University, Stanford, CA, USA
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
Division of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA
Division of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA
Division of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA Objective Multiple sclerosis (MS) is associated with substantial morbidity. The impact of comorbidity on MS is unknown, but comorbidity may explain some of the unpredictable progression. Comorbidity is common in the general population, and is associated with adverse health outcomes. To begin understanding the impact of comorbidity on MS, we need to know the breadth, type, and frequencies of comorbidities among MS patients. Using the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry, we aimed to describe comorbidities and their demographic predictors in MS. Methods In October 2006, we queried NARCOMS participants regarding physical comorbidities. Of 16,141 participants meeting the inclusion criteria, 8983 (55.7%) responded. Results
Comorbidity was relatively common; if we considered conditions which are very likely to be accurately self-reported, then 3280 (36.7%) reported at least one physical comorbidity. The most frequently reported comorbidities were hypercholesterolemia (37%), hypertension (30%), and arthritis (16%). Associated with the risk of comorbidity were being male [females vs. males, odds ratio (OR) 0.77; 0.69–0.87]; age (age >60 years vs. age Conclusions Comorbidity is common in MS and similarly associated with socioeconomic status.
Key Words: comorbidity • epidemiology • multiple sclerosis • socioeconomic status
Multiple Sclerosis, Vol. 14, No. 8,
1091-1098 (2008) This article has been cited by other articles:
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44 years, OR 5.91; 4.95–7.06); race (African Americans vs. Whites, OR 1.46; 1.06–2.03); and socioeconomic status (Income <$15,000 vs. Income >$100,000, OR 1.37; 1.10–1.70). 
