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Vitamin D receptor gene polymorphism is associated with reduced disability in multiple sclerosis

Keele Multiple Sclerosis Research Group, Department of Neurology, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire, UK

J Woolmore

Keele Multiple Sclerosis Research Group, Department of Neurology, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire, UK

E Pye

Keele Multiple Sclerosis Research Group, Department of Neurology, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire, UK

J Partridge

Keele Multiple Sclerosis Research Group, Department of Neurology, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire, UK

M Boggild

Walton Centre for Neurology and Neurosurgery, Lower Lane, Liverpool, UK

C Young

Walton Centre for Neurology and Neurosurgery, Lower Lane, Liverpool, UK

A Fryer

Human Genomics Research Group, Institute of Science and Technology in Medicine, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire, UK

PR Hoban

Human Genomics Research Group, Institute of Science and Technology in Medicine, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire, UK

N Rukin

Human Genomics Research Group, Institute of Science and Technology in Medicine, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire, UK

J Alldersea

Human Genomics Research Group, Institute of Science and Technology in Medicine, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire, UK

RC Strange

Keele Multiple Sclerosis Research Group, Department of Neurology, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire, UK; Human Genomics Research Group, Institute of Science and Technology in Medicine, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire, UK

CP Hawkins

Keele Multiple Sclerosis Research Group, Department of Neurology, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire, UK; Human Genomics Research Group, Institute of Science and Technology in Medicine, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire, UK clive{at}hawkins150.freeserve.co.uk

Ultraviolet radiation (UVR) may contribute to multiple sclerosis (MS) outcome by a mechanism involving vitamin D and the vitamin D receptor (VDR). In 512 patients with MS duration of 10 or more years, we studied the association of VDR single nucleotide polymorphisms (A/G¹²²⁹, C/G³⁴⁴⁴, G/A³⁹⁴⁴, CC²⁰⁹⁶⁵, CC³⁰⁰⁵⁶, F/f³⁰⁸⁷⁵, C/T⁴⁸²⁰⁰, T/t⁶⁵⁰¹³) with outcome or disability. ff³⁰⁸⁷⁵ frequency was lower in cases with EDSS 6.0 than with scores < 6.0 (odds ratio = 0.38, 95% CI = 0.20–0.70). The association of ff³⁰⁸⁷⁵ with outcome was not mediated by cumulative exposure to UVR as assessed by questionnaire; low exposure (odds ratio = 0.42, 95% CI = 0.14–1.34) and high exposure (odds ratio = 0.34, 95% CI = 0.16–0.73).

Key Words: disability evaluation • EDSS • multiple sclerosis • MSSS • ultraviolet radiation • vitamin D receptor

This version was published on November 1, 2008

Multiple Sclerosis, Vol. 14, No. 9, 1280-1283 (2008)
DOI: 10.1177/1352458508094643


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