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Movement disorders in multiple sclerosis: causal or coincidental association?

Department of Neuroscience, Institute of Neurology, Catholic University, Rome, Italy; Don Gnocchi Foundation, Department of Neurorehabilitation, Rome, Italy

AR Bentivoglio

Department of Neuroscience, Institute of Neurology, Catholic University, Rome, Italy

G Frisullo

Department of Neuroscience, Institute of Neurology, Catholic University, Rome, Italy

A Fasano

Department of Neuroscience, Institute of Neurology, Catholic University, Rome, Italy

F Soleti

Department of Neuroscience, Institute of Neurology, Catholic University, Rome, Italy

R Iorio

Department of Neuroscience, Institute of Neurology, Catholic University, Rome, Italy

G Loria

Department of Neuroscience, Institute of Neurology, Catholic University, Rome, Italy

AK Patanella

Department of Neuroscience, Institute of Neurology, Catholic University, Rome, Italy

A Marti

Department of Neuroscience, Institute of Neurology, Catholic University, Rome, Italy

T Tartaglione

Department of Bioimaging and Radiological Sciences, Institute of Radiology, Catholic University, Rome, Italy

PA Tonali

Department of Neuroscience, Institute of Neurology, Catholic University, Rome, Italy; Don Gnocchi Foundation, Department of Neurorehabilitation, Rome, Italy

AP Batocchi

Department of Neuroscience, Institute of Neurology, Catholic University, Rome, Italy; Don Gnocchi Foundation, Department of Neurorehabilitation, Rome, Italy annapaola.batocchi{at}rm.unicatt.it

Despite the relatively frequent involvement of the basal ganglia and subthalamic nucleus by multiple sclerosis (MS) plaques, movement disorders (MD), other than tremor secondary to cerebellar or brainstem lesions, are uncommon clinical manifestations of MS. MD were present in 12 of 733 patients with MS (1.6%): three patients had parkinsonism, two blepharospasm, five hemifacial spasm, one hemidystonia, and one tourettism. MD in patients with MS are often secondary to demyelinating disease. Also in cases without response to steroid treatment and demyelinating lesions in critical regions, it is not possible to exclude that MD and MS are causally related.

Key Words: blepharospasm • hemidystonia • hemifacial spasm • movement disorders • multiple sclerosis • parkinsonism • tourettism

This version was published on November 1, 2008

Multiple Sclerosis, Vol. 14, No. 9, 1284-1287 (2008)
DOI: 10.1177/1352458508094883


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