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25-Hydroxyvitamin D in cerebrospinal fluid during relapse and remission of multiple sclerosis

Institute of Immunology, Faculty of Medicine, University of Oslo, Oslo, Norway, trygve.holmoy{at}rr-research.no, Department of Neurology, Oslo University Hospital - Ullevål, Oslo, Norway

Stine Marit Moen

Department of Neurology, Oslo University Hospital - Ullevål, Oslo, Norway

Thomas A Gundersen

Vitas AS, Oslo, Norway

Michael F Holick

Department of Medicine, Boston University Medical Center, Boston, MA, USA

Enrico Fainardi

Neurological Clinic, University of Ferrara, Ferrara, Italy

Massimiliano Castellazzi

Neurological Clinic, University of Ferrara, Ferrara, Italy

Ilaria Casetta

Neurological Clinic, University of Ferrara, Ferrara, Italy

Hypovitaminosis D may play a role in multiple sclerosis (MS), but little is known about intrathecal vitamin D. 25-Hydroxyvitamin D was measured in cerebrospinal fluid and sera from 36 patients with relapsing-remitting MS, 20 patients with other inflammatory neurological diseases and 18 patients with non-inflammatory neurological diseases with liquid chromatography-mass spectrometry. There were no significant differences in cerebrospinal fluid concentrations of 25-hydroxyvitamin D, but the cerebrospinal fluid:serum ratio was significantly lower in MS compared with other inflammatory neurological diseases (p=0.0012) and non-inflammatory neurological diseases (p=0.041) patients. The concentrations of 25-hydroxyvitamin D in cerebrospinal fluid and serum were positively correlated and their ratio was similar to that of albumin. Neither the concentrations of 25-hydroxyvitamin D in cerebrospinal fluid or serum nor their ratio were associated with the presence of relapses or gadolinium-enhanced lesions. These results do not support that 25-hydroxyvitamin D is actively transported to the cerebrospinal fluid, or that the cerebrospinal fluid or serum levels or their ratio exert a major impact on MS activity.

Key Words: vitamin D • multiple sclerosis • cerebrospinal fluid • immunology

This version was published on November 1, 2009

Multiple Sclerosis, Vol. 15, No. 11, 1280-1285 (2009)
DOI: 10.1177/1352458509107008


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