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Multiple Sclerosis
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1352458509107009v1
15/11/1356    most recent
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First trimester interleukin 8 levels are associated with postpartum relapse in multiple sclerosis

Rinze F Neuteboom

Department of Neurology, Erasmus MC, Rotterdam, The Netherlands, MS Center ErasMS, Rotterdam, The Netherlands

Evert Verbraak

MS Center ErasMS, Rotterdam, The Netherlands, Department of Immunology, Erasmus MC, Rotterdam, The Netherlands

Jane SA Voerman

MS Center ErasMS, Rotterdam, The Netherlands, Department of Immunology, Erasmus MC, Rotterdam, The Netherlands

Marjan van Meurs

MS Center ErasMS, Rotterdam, The Netherlands, Department of Immunology, Erasmus MC, Rotterdam, The Netherlands

Eric AP Steegers

Department of Obstetrics and Gynecology, Erasmus MC, Rotterdam, The Netherlands

Christianne JM de Groot

Department of Obstetrics and Gynecology, Medisch centrum Haaglanden, The Hague, The Netherlands

Jon D Laman

MS Center ErasMS, Rotterdam, The Netherlands, Department of Immunology, Erasmus MC, Rotterdam, The Netherlands

Rogier Q Hintzen

Department of Neurology, Erasmus MC, Rotterdam, The Netherlands, MS Center ErasMS, Rotterdam, The Netherlands, r.hintzen{at}erasmusmc.nl

Pregnancy has an ameliorating effect on multiple sclerosis (MS), but directly after delivery the risk of a relapse is increased. The pro-inflammatory chemokine interleukin 8 is associated with disease activity. We aimed to investigate whether pregnancy-induced fluctuations of interleukin 8 correlate with periods of enhanced and diminished disease activity. Thirty-six women with MS were prospectively studied before, during and after pregnancy. Serum levels of interleukin 8 were significantly decreased during the third trimester (p = 0.03). High first trimester serum levels of interleukin 8 were associated with a high risk of postpartum relapse (p = 0.007). These results help us to further understand the altered disease course during pregnancy.

Key Words: autoimmunity • tolerance • pregnancy • chemokines

This version was published on November 1, 2009

Multiple Sclerosis, Vol. 15, No. 11, 1356-1358 (2009)
DOI: 10.1177/1352458509107009
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