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Angiotensin-converting enzyme (ACE) and ACE2 levels in the cerebrospinal fluid of patients with multiple sclerosis

Department of Geriatric Medicine, Graduate School of Medicine, Ehime University, Ehime, Japan mz1965kawajj{at}khc.biglobe.ne.jp

M Mogi

Department of Molecular Cardiovascular Biology and Pharmacology, Graduate School of Medicine, Ehime University, Ehime, Japan

N Higaki

Department of Anesthesiology and Resuscitology, Graduate School of Medicine, Ehime University, Ehime, Japan

T Matsuoka

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Y Ohyagi

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

K Tsukuda

Department of Molecular Cardiovascular Biology and Pharmacology, Graduate School of Medicine, Ehime University, Ehime, Japan

K Kohara

Department of Geriatric Medicine, Graduate School of Medicine, Ehime University, Ehime, Japan

M Horiuchi

Department of Molecular Cardiovascular Biology and Pharmacology, Graduate School of Medicine, Ehime University, Ehime, Japan

T Miki

Department of Geriatric Medicine, Graduate School of Medicine, Ehime University, Ehime, Japan

JI Kira

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Background

We reported a reduction in the levels of angiotensin II in cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS).

Objective and methods

To clarify the mechanism underlying this reduction, we assayed angiotensin-converting enzyme (ACE) and ACE2 concentrations along with angiotensin II concentrations in CSF samples from 20 patients with MS and 17 controls with non-neurological diseases.

Results

ACE levels were significantly elevated in patients with MS compared with controls (48.42 ± 4.84 vs 44.71 ± 3.9 pg/mL), whereas ACE2 levels were significantly reduced (2.56 ± 0.26 vs 2.78 ± 0.24 pg/mL), acting toward a normalization of angiotensin II levels.

Conclusion

These results further indicate an alteration of the intrathecal renin-angiotensin system in patients with MS.

Key Words: angiotensin-converting enzyme • cerebrospinal fluid • multiple sclerosis • renin-angiotensin system

This version was published on February 1, 2009

Multiple Sclerosis, Vol. 15, No. 2, 262-265 (2009)
DOI: 10.1177/1352458508097923


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