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Neuromyelitis optica and multiple sclerosis in sisters

Multiple Sclerosis Society and Multiple Sclerosis Clinic, International Center of Neurological Restoration, Havana, Cuba

L Ramón-Pérez

Neurological Service and Direction Department, Health International Center, La Pradera

A Saiz

Laboratory of Experimental Neurology and Immunology, Hospital Clínic Barcelona, Barcelona, Spain

P Llerena-Fernández

Neurological Service and Direction Department, Health International Center, La Pradera

L Fernández-Fernández

Neurological Service and Direction Department, Health International Center, La Pradera

G Ercilla

Laboratory of Experimental Neurology and Immunology, Hospital Clínic Barcelona, Barcelona, Spain

D Grass-Fernández

Multiple Sclerosis Society and Multiple Sclerosis Clinic, International Center of Neurological Restoration, Havana, Cuba

MA Robinson-Agramonte

Multiple Sclerosis Society and Multiple Sclerosis Clinic, International Center of Neurological Restoration, Havana, Cuba

K Romero-García

Multiple Sclerosis Society and Multiple Sclerosis Clinic, International Center of Neurological Restoration, Havana, Cuba

R Macías-Betancourt

Multiple Sclerosis Society and Multiple Sclerosis Clinic, International Center of Neurological Restoration, Havana, Cuba

R Galvizu-Sánchez

Multiple Sclerosis Society and Multiple Sclerosis Clinic, International Center of Neurological Restoration, Havana, Cuba

C Otero-Motolá

Neurological Service and Direction Department, Health International Center, La Pradera

M Sojo-Gómez

Multiple Sclerosis Society and Multiple Sclerosis Clinic, International Center of Neurological Restoration, Havana, Cuba

C Aguilar-Arias

Multiple Sclerosis Society and Multiple Sclerosis Clinic, International Center of Neurological Restoration, Havana, Cuba

M Rodríguez-Cordero

Multiple Sclerosis Society and Multiple Sclerosis Clinic, International Center of Neurological Restoration, Havana, Cuba

A González-Quevedo

Biochemistry Department , Institute of Neurology and Neurosurgery, Havana, Cuba

Introduction

The association of neuromyelitis optica (NMO) and multiple sclerosis (MS) has been reported, but details of the cases were not described. We report two Venezuelan Caucasian sisters with human leukocyte antigen (HLA) typing.

Results

Patient 1 fulfilled McDonald, et al. criteria with HLA A*24; B*07,*15; DRB1*01,*16 (DR2 positive). Patient 2 fulfilled the NMO revised criteria of Wingerchuck, et al. with HLA A*02,*24; B*07,*40; DRB1*04,*08, similar to Canadian aboriginal NMO cases and the Yukpa population from Venezuela.

Conclusion

These cases confirmed the coexistence of NMO and MS in sisters, and further studies are needed to understand the genetic linkage between these diseases.

Key Words: Devic’s disease • human leukocyte antigen • multiple sclerosis • neuromyelitis optica • relapsing neuromyelitis optica

This version was published on February 1, 2009

Multiple Sclerosis, Vol. 15, No. 2, 269-271 (2009)
DOI: 10.1177/1352458508097921


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