| Sign In to gain access to subscriptions and/or personal tools. |
Clinical and diagnostic aspects of multiple sclerosis and acute monophasic encephalomyelitis in pediatric patients: a single centre prospective studyMultiple Sclerosis Centre of The Veneto Region, University of Padova, Padova, Italy; First Neurology Clinic, University of Padova, Padova, Italy matteo.atzori{at}unipd.it
Department of Pediatrics, University of Padova, Padova, Italy
Multiple Sclerosis Centre of The Veneto Region, University of Padova, Padova, Italy; First Neurology Clinic, University of Padova, Padova, Italy
Multiple Sclerosis Centre of The Veneto Region, University of Padova, Padova, Italy; First Neurology Clinic, University of Padova, Padova, Italy
Department of Pediatrics, University of Padova, Padova, Italy
Department of Pediatrics, University of Padova, Padova, Italy
Department of Pediatrics, University of Padova, Padova, Italy
Department of Pediatrics, University of Padova, Padova, Italy
Multiple Sclerosis Centre of The Veneto Region, University of Padova, Padova, Italy; First Neurology Clinic, University of Padova, Padova, Italy
Multiple Sclerosis Centre of The Veneto Region, University of Padova, Padova, Italy; First Neurology Clinic, University of Padova, Padova, Italy
Multiple Sclerosis Centre of The Veneto Region, University of Padova, Padova, Italy; First Neurology Clinic, University of Padova, Padova, Italy Objective The purpose of the study was to compare and contrast the initial presenting demographic, clinical, neuroimaging, and laboratory features in a cohort of children affected from multiple sclerosis (MS) or acute disseminated encephalomyelitis (ADEM). Methods
A 12-year prospective study was conducted in 68 pediatric patients (age Results At clinical onset, children who developed MS during the follow-up (48 patients; 34 females, 14 males; mean age at onset: 14.4 ± 2.5) significantly differed from children affected by ADEM (20 patients; 8 females, 12 males; mean age at onset: 8.1 ± 3.8 ) for the following parameters: prevalence of females affected (female/male ratio: 2.8 versus 0.6, P = 0.03); mean age at onset (P < 0.001); monosymptomatic onset (73% vs 30%, P = 0.002); encephalopathy-like onset (0% vs 50%, P < 0.001); presence of oligoclonal IgG bands (IgGOB) in CSF (83% vs 10%, P < 0.001); and periventricular (79% vs 20%, P < 0.001), brain stem (12.5% vs 60%, P = 0.000), and basal ganglia (10% vs 50%, P < 0.001) lesions at MRI. Conclusions Our findings depict a pattern of demographic, clinical, neuroimaging, and laboratory findings that can help to distinguish, at clinical onset, children suffering from ADEM from those who will develop MS. Childhood-onset MS seems not to differ from adult-onset MS from both clinical and paraclinical features.
Key Words: acute disseminated encephalomyelitis • children • multiple sclerosis
This version was published on March
1, 2009 Multiple Sclerosis, Vol. 15, No. 3,
363-370 (2009) |
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 |
|
|
 |
Sign In to gain access to subscriptions and/or personal tools.
17 years) who presented with a first episode of central nervous system inflammation suggestive of a demyelinating multifocal pathology. All patients had undergone magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) examination. The mean follow-up period, as at ending on December 31, 2007, was 6.8 ± 2.7 years (range 3.2–12.6 years).