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Multiple Sclerosis
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research-article

Multiple sclerosis-associated retroviral agent (MSRV)-stimulated cytokine production in patients with relapsing-remitting multiple sclerosis

M Saresella

Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi ONLUS Foundation IRCCS, Via Capecelatro, 66, Milano 20148, Italy

A Rolland

Laboratoire d’Immunochimie,CEA/INSERUM-U548, 17 rue des Martyrs 38054 Grenoble, France

I Marventano

Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi ONLUS Foundation IRCCS, Via Capecelatro, 66, Milano 20148, Italy

R Cavarretta

Multiple Sclerosis Unit, Don C. Gnocchi ONLUS Foundation, IRCCS, Via Capecelatro, 66, Milano 20148, Italy

D Caputo

Multiple Sclerosis Unit, Don C. Gnocchi ONLUS Foundation, IRCCS, Via Capecelatro, 66, Milano 20148, Italy

P Marche

Laboratoire d’Immunochimie,CEA/INSERUM-U548, 17 rue des Martyrs 38054 Grenoble, France

H Perron

GeNeuro, Geneva; 1228 Plan-Lesouates, Switzerland

M Clerici

Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi ONLUS Foundation IRCCS, Via Capecelatro, 66, Milano 20148, Italy; Chair of Immunology, Department of Biomedical Sciences and Technologies, University of Milano, Via Fratelli Cervi 93, Milano 20090, Italy mario.clerici{at}unimi.it

Background

Human endogenous retroviruses are suggested to play a pathogenic role in multiple sclerosis (MS); one of such retroviruses, the MS-associated retroviral agent (MSRV) has repeatedly been isolated in MS patients.

Objective and methods

We analyzed cytokine profiles in MSRV envelope protein (MSRV ENV-SU)-stimulated peripheral blood mononuclear cells of 30 relapsing-remitting MS patients with either acute (AMS) (n = 13) or stable (SMS) (n = 17) disease. Results suggest that MSRV ENV-SU induces the production of inflammatory cytokines, including tumor necrosis factor-{alpha} (P < 0.05) and interferon-{gamma} (P < 0.004) in AMS patients and of interleukin-10 (P < 0.05), an inflammation-dampening cytokine, in SMS individuals.

Conclusions

These data strengthen the hypothesis indicating that MSRV could be involved in the pathogenesis of MS.

Key Words: cytokines • ENV-SU protein • human endogenous retroviruses (HERV) • immunology • multiple sclerosis • T lymphocytes

This version was published on April 1, 2009

Multiple Sclerosis, Vol. 15, No. 4, 443-447 (2009)
DOI: 10.1177/1352458508100840
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