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Multiple Sclerosis
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brief-report

Erythrocyte membrane fatty acids in patients with multiple sclerosis

GM Hon

Department of Bio-Medical Sciences, Faculty of Health and Wellness Science, Cape Peninsula University of Technology, P O Box 1906, Bellville, 7530, Cape Town, South Africa

MS Hassan

Department of Bio-Medical Sciences, Faculty of Health and Wellness Science, Cape Peninsula University of Technology, P O Box 1906, Bellville, 7530, Cape Town, South Africa

SJ van Rensburg

National Health Laboratory Services, South Africa

S Abel

PROMEC Unit and NIRU, South Africa

DW Marais

South African Medical Research Council, South Africa

P van Jaarsveld

South African Medical Research Council, South Africa

CM Smuts

South African Medical Research Council, South Africa; North-West University (Potchefstroom Campus), South Africa

F Henning

Division of Neurology, Tygerberg Academic Hospital, Western Cape, South Africa

RT Erasmus

Division of Chemical Pathology, University of Stellenbosch, South Africa

T Matsha

Department of Bio-Medical Sciences, Faculty of Health and Wellness Science, Cape Peninsula University of Technology, P O Box 1906, Bellville, 7530, Cape Town, South Africamatshat{at}cput.ac.za

Background

Reports on fatty acids levels in multiple sclerosis remain inconclusive.

Objective

To determine the erythrocyte membrane fatty acid levels in multiple sclerosis patients and correlate with Kurtzke Expanded Disability Status Scale.

Methods

Fatty acid composition of 31 multiple sclerosis and 30 control individuals were measured by gas chromatography.

Results

The membrane phosphatidylcholine C20:4n – 6 concentration was lower in the multiple sclerosis patients when compared to that of the control group, P = 0.04 and it correlated inversely with the EDSS and FSS.

Conclusion

Decrease in C20:4n – 6 in the erythrocyte membrane could be an indication of depleted plasma stores, and a reflection of disease severity.

Key Words: multiple sclerosis • outcome measurement • relapsing/remitting

This version was published on June 1, 2009

Multiple Sclerosis, Vol. 15, No. 6, 759-762 (2009)
DOI: 10.1177/1352458509103321
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