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Prominent brainstem and cerebellar involvement in multiple sclerosis with psoriasis

Department of Neurology, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia

JM Greer

The University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia

MP Pender

Department of Neurology, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia; The University of Queensland, School of Medicine, Brisbane, Queensland, Australiam.hawes{at}uq.edu.au

Introduction

We identified a subgroup of 20 patients with multiple sclerosis (MS) and psoriasis within a total group of 692 patients with MS.

Results

There was a high (80%) incidence of brainstem and/or cerebellar involvement and a high mean (±SD) Multiple Sclerosis Severity Score (6.06 ± 2.88) in this subgroup. Of the patients who were human leukocyte antigen typed, 53% carried the MS-associated allele, DRB1*1501, and 27% carried the psoriasis-associated DRB1*07 allele.

Conclusion

The high incidence of brainstem and cerebellar involvement might be explained by the greater severity of MS and the high frequency (60%) of carriage of DRB1*04, DRB1*07, and/or DRB1*13 alleles, which are associated with brainstem and cerebellar involvement in MS.

Key Words: brainstem • cerebellum • HLA • multiple sclerosis • psoriasis

Multiple Sclerosis, Vol. 15, No. 6, 763-766 (2009)
DOI: 10.1177/1352458509103612


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