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Protective role of the HLA–A*02 allele in Portuguese patients with multiple sclerosis

Departamento de Neurologia, Centro Hospitalar do Porto – Hospital de Santo António, Porto, Portugalanadmsilva{at}yahoo.com

A Bettencourt

UMIB – Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UP), Porto, Portugal

C Pereira

UMIB – Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UP), Porto, Portugal

E Santos

Departamento de Neurologia, Centro Hospitalar do Porto – Hospital de Santo António, Porto, Portugal

C Carvalho

Unidade de Investigação, Centro de Genética Médica Jacinto de Magalhães, Porto, Portugal

D Mendonça

Departamento do estudo de populações, Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UP), Porto, Portugal

PP Costa

UMIB – Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UP), Porto, Portugal; Unidade de Investigação, Centro de Genética Médica Jacinto de Magalhães, Porto, Portugal

L Monteiro

Departamento de Neurologia, Centro Hospitalar do Porto – Hospital de Santo António, Porto, Portugal

B Martins

UMIB – Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UP), Porto, Portugal; Unidade de Investigação, Centro de Genética Médica Jacinto de Magalhães, Porto, Portugal

Background

Multiple sclerosis (MS) is associated with human leukocyte antigen (HLA) HLA–DRB1*15. Recent evidence that CD8 T cells are implicated in MS suggests that HLA class I may also contribute. An association of HLA–A*02 and A*03 alleles has been described.

Objectives

We examined the influence of HLA–A*02 and HLA–A*03 in Portuguese patients with MS, independently of HLA–DRB1*15 using a logistic regression model.

Conclusions

DRB1*15 increased the risk of developing MS and HLA–A*02 decreased the risk. A*03 had no effect. To analyze if HLA–A*02 association was independent from DRB1*15, an interaction between these two alleles was introduced in the model; no significant interaction was found.

Key Words: genetic susceptibility • HLA class I • multiple sclerosis • Portugal

Multiple Sclerosis, Vol. 15, No. 6, 771-774 (2009)
DOI: 10.1177/1352458509104588


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