This Article Full Text (PDF) All Versions of this Article: 1352458509104586v1 15/7/802    most recent References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Yeh, E. Articles by Ramanathan, M Search for Related Content PubMed PubMed Citation Articles by Yeh, E. Articles by Ramanathan, M Social Bookmarking                         What's this?

Retinal nerve fiber thickness in inflammatory demyelinating diseases of childhood onset

Pediatric Multiple Sclerosis Center, State University of New York at Buffalo, Buffalo, New York, USA; Departments of Neurology, State University of New York at Buffalo, Buffalo, New York, USA

B Weinstock-Guttman

Pediatric Multiple Sclerosis Center, State University of New York at Buffalo, Buffalo, New York, USA; Departments of Neurology, State University of New York at Buffalo, Buffalo, New York, USAbguttman{at}thejni.org

N Lincoff

Ross Eye Institute, State University of New York at Buffalo, Buffalo, New York, USA; Ophthalmology, State University of New York at Buffalo, Buffalo, New York, USA

J Reynolds

Ross Eye Institute, State University of New York at Buffalo, Buffalo, New York, USA; Ophthalmology, State University of New York at Buffalo, Buffalo, New York, USA

A Weinstock

Departments of Neurology, State University of New York at Buffalo, Buffalo, New York, USA

N Madurai

Pediatric Multiple Sclerosis Center, State University of New York at Buffalo, Buffalo, New York, USA

N Agarwal

Pediatric Multiple Sclerosis Center, State University of New York at Buffalo, Buffalo, New York, USA; Departments of Neurology, State University of New York at Buffalo, Buffalo, New York, USA

P Buch

Ross Eye Institute, State University of New York at Buffalo, Buffalo, New York, USA; Ophthalmology, State University of New York at Buffalo, Buffalo, New York, USA

M Karpinski

Pediatric Multiple Sclerosis Center, State University of New York at Buffalo, Buffalo, New York, USA; Departments of Neurology, State University of New York at Buffalo, Buffalo, New York, USA

M Ramanathan

Pediatric Multiple Sclerosis Center, State University of New York at Buffalo, Buffalo, New York, USA; Departments of Neurology, State University of New York at Buffalo, Buffalo, New York, USA; Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York, USA

Purpose

To evaluate retinal nerve fiber layer thickness (RNFLT) using optical coherence tomography (OCT) in children with acquired demyelinating diseases.

Methods

This is a cross-sectional study of patients seen between 2006–2008 at the Pediatric MS Center of the Jacobs Neurological Institute. Consensus definitions for pediatric demyelinating disease were followed. All children received OCT testing and assessment of visual acuity (VA) using Snellen and low contrast letter acuity (LCLA) charts.

Results

Thirty-eight children diagnosed with acquired demyelinating disease, 15 healthy controls, and five children with other neurological disorders (OND) were included. Average RNFLT in healthy controls was 107 ± 12 µm(n = 30) versus 108 ± 5 µm (n = 10) in OND controls. In children with multiple sclerosis, average RNFLT ± SD was 99 ± 14 µm in unaffected (n = 24) versus 83 ± 12 µmin eyes affected by optic neuritis ("affected eyes") (n = 10). Average RNFLT in children with acute disseminated encephalomyelitis and transverse myelitis was 102 ± 15 µm in unaffected (n = 18) versus 67 ± 17 µm in affected eyes (n = 6). In children with optic neuritis (ON), average RNFLT ± SD was 97 ± 13 µm in unaffected (n = 5) versus 89 ± 12 µm in affected eyes (n = 9). Differences between children with demyelinating disease and controls and between ON and nonON eyes were statistically significant (P < 0.001). Bivariate correlations of RNFLT with LCLA (P = 0.002) and VA (P < 0.001) were significant.

Conclusions

OCT may be a valuable tool for the assessment and monitoring of anterior optic pathway dysfunction in children with demyelinating diseases.

Key Words: acute disseminated encephalomyelitis • low contrast letter acuity • multiple sclerosis • optical coherence tomography

This version was published on July 1, 2009

Multiple Sclerosis, Vol. 15, No. 7, 802-810 (2009)
DOI: 10.1177/1352458509104586


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?