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Multiple Sclerosis
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research-article

Cognitive dysfunction in primary progressive multiple sclerosis: a neuropsychological and MRI study

M Ukkonen

Department of Neurology and Rehabilition, Tampere University Hospital, Tampere, Finland; Medical School, University of Tampere, Tampere, Finland; National Graduate School of Clinical Investigation, Finlandmaritta.ukkonen{at}pshp.fi

T Vahvelainen

Department of Neurology and Rehabilition, Tampere University Hospital, Tampere, Finland

P Hämäläinen

Masku Neurological Rehabilitation Centre. Masku, Finland

P Dastidar

Department of Diagnostic Imaging, Tampere University Hospital, Tampere, Finland

I Elovaara

Department of Neurology and Rehabilition, Tampere University Hospital, Tampere, Finland; National Graduate School of Clinical Investigation, Finland

Although cognitive dysfunction is known to occur in multiple sclerosis (MS), only few studies have reported cognitive performance in patients with primary progressive MS (PPMS). To find out the pattern of cognitive performance in PPMS, 28 PPMS patients underwent an extensive battery of neuropsychological tests. The results were compared to those of healthy controls (n = 20) and patients with secondary progressive MS (SPMS, n = 28). Furthermore, the results of neuropsychological tests in PPMS were correlated to magnetic resonance imaging findings. Our study showed that the PPMS patients have deficits in several cognitive domains when compared to age-matched and education-matched controls, but the cognitive impairment in the PPMS and SPMS patients appeared to be similar. Cognitive deficits in PPMS patients correlated with diffuse brain lesion, T1- and T2-lesion load, but no correlations were found with atrophy.

Key Words: cognitive function • magnetic resonance imaging • primary progressive multiple sclerosis

This version was published on September 1, 2009

Multiple Sclerosis, Vol. 15, No. 9, 1055-1061 (2009)
DOI: 10.1177/1352458509106231
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