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Multiple Sclerosis
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case-report

Foreign accent syndrome as a first sign of multiple sclerosis

JB Chanson

Service de Neurologie, Hôpital Civil, 1 place de l’Hôpital, Strasbourg, Francejb.chanson{at}hotmail.fr

S Kremer

Service de Neuroradiologie, Hôpital de Hautepierre, Strasbourg, France

F Blanc

Service de Neurologie, Hôpital Civil, 1 place de l’Hôpital, Strasbourg, France

C Marescaux

Service de Neurologie, Hôpital Civil, 1 place de l’Hôpital, Strasbourg, France

IJ Namer

Service de Médecine Nucléaire, Hôpital de Hautepierre, Strasbourg, France

J de Seze

Service de Neurologie, Hôpital Civil, 1 place de l’Hôpital, Strasbourg, France

Background

Foreign accent syndrome (FAS) consists of a speech rhythm disorder different from dysarthia or aphasia. It is unusually met in multiple sclerosis (MS).

Objective

We report a case of FAS as an initial symptom of a MS.

Methods

A right-handed French woman developed an isolated German foreign accent. Brain magnetic resonance imaging (MRI), SPECT and analysis of CSF were performed.

Results

Brain MRI revealed a large hypersignal on T2-weighted images in the left prerolandic white matter. Single photon emission computed tomography showed a right prerolandic hypoperfusion. Unmatched oligoclonal bands in cerebrospinal fluid and occurrence of new abnormal hypersignals on the following MRI led us to diagnose MS.

Conclusion

FAS may be the first symptom of MS. It could result from extensive disturbances of brain function involving the right hemisphere.

Key Words: foreign accent syndrome • functional imaging • multiple sclerosis

This version was published on September 1, 2009

Multiple Sclerosis, Vol. 15, No. 9, 1123-1125 (2009)
DOI: 10.1177/1352458509106611
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