This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Scopus Google Scholar Articles by Etemadifar, M Articles by Maghzi, A. PubMed PubMed Citation Articles by Etemadifar, M Articles by Maghzi, A. Social Bookmarking                         What's this?

Multiple sclerosis and neurofibromatosis type 1: report of seven patients from Iran

Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran; Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Isfahan Research Committee of Multiple Sclerosis (IRCOMS), Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

F Fatehi

Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran; Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Isfahan Research Committee of Multiple Sclerosis (IRCOMS), Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran; Isfahan Medical Education Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

MA Sahraian

Department of Neurology and Sina MS Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

A Borhanihaghighi

Department of Neurology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

PM Ardestani

Department of Anatomy, Neuroscience lab II, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

M Kaji-Esfahani

Department of Radiology, Islamic Azad University of Najafabad, Isfahan, Iran

AH Maghzi

Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Isfahan Research Committee of Multiple Sclerosis (IRCOMS), Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran; Neuroimmunology unit, Neuroscience Center, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UKMaghzi{at}edc.mui.ac.ir

Introduction

Co-occurrence of multiple sclerosis (MS) and neurofibromatosis type 1 (NF1) is rare.

Case reports

In this study, we describe the clinical and neuroimaging features of seven patients with NF1 and MS. In our patients, six patients with MS were women, in all of them history of NF1 existed. Three of our patients had primary progressive, one had secondary progressive MS, and three relapsing–remitting MS. Optic neuritis as presenting symptoms was seen in three patients, and motor manifestation as presenting symptom was observed in three patients. The risk of having both NF1 and MS seemed to be higher than would be expected based on the prevalence rates of the two diseases in the general population.

Conclusion

The findings of this study suggest a possible casual relationship between MS and NF1, indicating higher risk of MS among patients with NF1.

Key Words: autoimmune • Iran • multiple sclerosis • neurofibromatosis

Multiple Sclerosis, Vol. 15, No. 9, 1126-1130 (2009)
DOI: 10.1177/1352458509106612


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?