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Resolution of CNS lesions following treatment of experimental allergic encephalomyelitis in macaques with monoclonal antibody to the CD 18 leukocyte integrin

Departments of Pathology

T L Richards

Radiology, University of Washington School of Medicine, Seattle, Washington 98195, USA

J Peterson

Departments of Pathology

R Petersen

Departments of Pathology

E C Alvord, Jr

Departments of Pathology

Experimental allergic encephalomyelitis (EAE) in macaques is an acute inflammatory and demyelinating disease of the central nervous system (CNS) which has been studied extensively as a model of the human demyelinating disease multiple sclerosis (MS). The in vivo administration of monoclonal antibodies against CD 18, the common β-chain of a leukocyte integrin, at the onset of clinical disease, significantly prolonged the survival of nine of 11 macaques (82%) and in some cases completely reversed the clinical appearance of disease. Treatment with anti-CD18 mAbs dramatically reduced the extent of inflammation in brain lesions as determined by magnetic resonance imaging (MRI). These improvements confirm that anti-CD18 mAbs are powerful anti-inflammatory agents in vivo and suggest that such mAbs may provide effective treatment of both demyelinating and inflammatory CNS diseases in man.

Key Words: EAE • non-human primates • monoclonal antibody therapy • CD18

Multiple Sclerosis, Vol. 2, No. 6, 259-266 (1997)
DOI: 10.1177/135245859700200601


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