This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Sekijima, Y Articles by Yanagisawa, N Search for Related Content PubMed Articles by Sekijima, Y Articles by Yanagisawa, N Social Bookmarking                         What's this?

Serial magnetic resonance imaging (MRI) study of a patient with Balo's concentric sclerosis treated with immunoadsorption plasmapheresis

Department of Medicine (Neurology), Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390, Japan

T Tokuda

Department of Medicine (Neurology), Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390, Japan

T Hashimoto

Department of Medicine (Neurology), Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390, Japan

C-S Koh

Department of Medicine (Neurology), Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390, Japan

S Shoji

Department of Medicine (Neurology), Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390, Japan

N Yanagisawa

Department of Medicine (Neurology), Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390, Japan

A 28-year-old Japanese woman with Balo's concentric sclerosis developed a rapidly progressive form of encephalopathy. Magnetic resonance imaging (MRI) showed multiple concentric lesions in the central white matter and the cerebellum. The administration of corticosteroid regimen resulted in little benefit Immunoadsorption plasmapheresis led to a remission within 1 month of onset Serial MRI study was described here for the first time, which allowed us to observe the development of concentric stuctures. The observation indicated that initially, a central core, a round demyelinated area, and surrounding edema appeared around a vessel. Subsequently, concentric demyelineated bands formed simultaneously, not centrifugally, with diminution of the edema. Analysis of cerebrospinal fluid showed elevated levels of interleukin-6 and tumor necrosis factor-. The success of immunoadsorption plasmapheresis therapy in this patient suggests that both humoral demyelinating factors and cell-mediated immunity may be involved in the pathogenesis of this disorder.

Key Words: Balo's concentric sclerosis • magnetic resonance imaging (MRI) • corticosteroid therapy • immunoadsorption plasmapheresis

Multiple Sclerosis, Vol. 2, No. 6, 291-294 (1997)
DOI: 10.1177/135245859700200605


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				S. Lindquist, N. Bodammer, J. Kaufmann, F. Konig, H.-J. Heinze, W. Bruck, and M. Sailer Histopathology and serial, multimodal magnetic resonance imaging in a multiple sclerosis variant Multiple Sclerosis, May 1, 2007; 13(4): 471 - 482. [Abstract] [PDF]

				D. Pohl, E. Waubant, B. Banwell, D. Chabas, T. Chitnis, B. Weinstock-Guttman, S. Tenembaum, and for the International Pediatric MS Study Group Treatment of pediatric multiple sclerosis and variants Neurology, April 17, 2007; 68(16_suppl_2): S54 - S65. [Abstract] [Full Text] [PDF]

				D Pohl, K Rostasy, B Krone, and F Hanefeld Balo's concentric sclerosis associated with primary human herpesvirus 6 infection J. Neurol. Neurosurg. Psychiatry, December 1, 2005; 76(12): 1723 - 1725. [Abstract] [Full Text] [PDF]

				L. Airas, T. Kurki, H. Erjanti, and R. J Marttila Successful pregnancy of a patient with Balo's concentric sclerosis Multiple Sclerosis, June 1, 2005; 11(3): 346 - 348. [Abstract] [PDF]

				G R. Moore, K Berry, J J. Oger, A J. Prout, D A Graeb, and R A Nugent Balo's concentric sclerosis: surviving normal myelin in a patient with a relapsing-remitting clinical course Multiple Sclerosis, December 1, 2001; 7(6): 375 - 382. [Abstract] [PDF]

				E. Karaarslan, A. Altintas, U. Senol, N. Yeni, A. Dincer, C. Bayindir, N. Karaagac, and A. Siva Balo's Concentric Sclerosis: Clinical and Radiologic Features of Five Cases AJNR Am. J. Neuroradiol., August 1, 2001; 22(7): 1362 - 1367. [Abstract] [Full Text] [PDF]

				G. IANNUCCI, M. MASCALCHI, F. SALVI, and M. FILIPPI Vanishing Balo-like lesions in multiple sclerosis J. Neurol. Neurosurg. Psychiatry, September 1, 2000; 69(3): 399 - 400. [Full Text] [PDF]