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Multiple sclerosis in childhood: clinical features of 149 cases

Centro Studi Sclerosi Multipla-Ospedale di Gallarate, Università di Milano;

V. Deplano

Dipartimento di Neuroscienze-Università di Cagliari

J. Faroni

Dipartimento di Scienze Neurologiche, Università La Sapienza-Roma

MG Grasso

Dipartimento di Scienze Neurologiche, Università La Sapienza-Roma, IRCCS S. Lucia, Ospedale di Riabilitazione-Roma

M. Liguori

Clinica di Malattie Nervose e Mentali-Università di Bari, Italy

G. Marrosu

Dipartimento di Neuroscienze-Università di Cagliari

C. Pozzilli

Dipartimento di Scienze Neurologiche, Università La Sapienza-Roma

IL Simone

Clinica di Malattie Nervose e Mentali-Università di Bari, Italy

M. Zaffaroni

Centro Studi Sclerosi Multipla-Ospedale di Gallarate, Università di Milano;

From the retrospective study of 3375 patients affected by clinically definite or probable multiple sclerosis (MS), 149 patients were collected with onset of the disease before the age of 16 years (4.4%). Female/male ratio was higher than that of the adult onset MS (AOMS) population (2.2 vs 1.6) particularly at ages of onset after 12 years (3.0, P=0.007 vs AOMS). Among initial symptoms, those suggesting brainstem dysfunction (25%) were more frequent compared to other systems and compared to AOMs symptoms; motor and sensory disturbances were slightly less frequent (respectively 17.5% and 18.3%). Optic neuritis appeared in 16.5% of cases with onset in childhood and in 16.2% of cases with AOMS, cerebellar disturbances respectively in 9.1 % and 7.7%. The first interattack interval and the clinical course of early onset MS did not differ significantly from AOMS. In early onset MS patients with disease duration < 8 years, cases with EDSS > 6 were slightly more frequent than in the AOMS group (P=0.04). The frequency of cases for different levels of disability was similar for disease duration > 8 years.

Key Words: multiple sclerosis • child neurology • age of onset • frequency

Multiple Sclerosis, Vol. 3, No. 1, 43-46 (1997)
DOI: 10.1177/135245859700300105


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