This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Giugni, E. Articles by Bozzao, L. Search for Related Content PubMed PubMed Citation Articles by Giugni, E. Articles by Bozzao, L. Social Bookmarking                         What's this?

MRI measures and their relations with clinical disability in relapsing-remitting and secondary progressive multiple sclerosis

Department of Neurological Sciences, University 'La Sapienza' of Rome

C. Pozzilli

Department of Neurological Sciences, University 'La Sapienza' of Rome

S. Bastianello

Department of Neurological Sciences, University 'La Sapienza' of Rome

C. Gasperini

Department of Neurological Sciences, University 'La Sapienza' of Rome

A. Paolillo

Department of Neurological Sciences, University 'La Sapienza' of Rome

T. Koudriavtseva

Department of Neurological Sciences, University 'La Sapienza' of Rome

M. Frontoni

Department of Neurological Sciences, University 'La Sapienza' of Rome

D. Farina

Department of Neurological Sciences, University 'La Sapienza' of Rome

L. Bozzao

Department of Neurological Sciences, University 'La Sapienza' of Rome

To further evaluate the relationship between clinical disability and Magnetic Resonance Imaging (MRI) lesion burden, we examined 85 patients with clinically definite multiple sclerosis (54 relapsing-remitting and 31 secondary progressive). This cross-sectional study reports on the correlations between total and infratentorial lesion volume on both T1 and T2 weighted images, and overall physical disability measured by Expanded Disability Status Scale, ambulation index and individual functional systems. Assessment of the hypointense lesion load on T1 weighted images rather than the hyperintense lesion load on T2 weighted images at brain MRI was shown to be useful for differentiating relapsing-remitting from secondary progressive Multiple Sclerosis. A weak relationship between disability and total lesion volume on both T1 and T2 weighted images was found in relapsing-remitting Multiple Sclerosis. In secondary progressive Multiple Sclerosis, infratentorial lesion volume on T2 weighted images represents the only marker of disability. Finally, the presence of cerebellar, brainstem and mental impairment was significantly associated to a greater total lesion volume on MRI, while no relationship was found with other functional systems.

Key Words: expanded disability status scale • functional systems • ambulation index • magnetic resonance imaging • Multiple Sclerosis • relapsing-remitting

Multiple Sclerosis, Vol. 3, No. 4, 221-225 (1997)
DOI: 10.1177/135245859700300401


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				M. Riva, V.N. Ikonomidou, J.J. Ostuni, P. van Gelderen, S. Auh, J.M. Ohayon, F. Tovar-Moll, N.D. Richert, J.H. Duyn, and F. Bagnato Tissue-Specific Imaging Is a Robust Methodology to Differentiate In Vivo T1 Black Holes with Advanced Multiple Sclerosis-Induced Damage AJNR Am. J. Neuroradiol., August 1, 2009; 30(7): 1394 - 1401. [Abstract] [Full Text] [PDF]

				D.K.B. Li, U. Held, J. Petkau, M. Daumer, F. Barkhof, F. Fazekas, J. A. Frank, L. Kappos, D. H. Miller, J. H. Simon, et al. MRI T2 lesion burden in multiple sclerosis: A plateauing relationship with clinical disability Neurology, May 9, 2006; 66(9): 1384 - 1389. [Abstract] [Full Text] [PDF]

				D. R Jeffery, N. Chepuri, D. Durden, and J. Burdette A pilot trial of combination therapy with mitoxantrone and interferon beta-1b using monthly gadolinium-enhanced magnetic resonance imaging Multiple Sclerosis, June 1, 2005; 11(3): 296 - 301. [Abstract] [PDF]

				S. A. Rizvi and M. A. Agius Current approved options for treating patients with multiple sclerosis Neurology, December 28, 2004; 63(12_suppl_6): S8 - S14. [Abstract] [Full Text]

				S J Hickman, G J Barker, P D Molyneux, and D H Miller Technical note: the comparison of hypointense lesions from 'pseudo-T1' and T1-weighted images in secondary progressive multiple sclerosis Multiple Sclerosis, October 1, 2002; 8(5): 433 - 435. [Abstract] [PDF]

				M. A. A. van Walderveen, G. J. Lycklama a Nijeholt, H. J. Ader, P. J. H. Jongen, C. H. Polman, J. A. Castelijns, and F. Barkhof Hypointense Lesions on T1-Weighted Spin-Echo Magnetic Resonance Imaging: Relation to Clinical Characteristics in Subgroups of Patients With Multiple Sclerosis Arch Neurol, January 1, 2001; 58(1): 76 - 81. [Abstract] [Full Text] [PDF]

				J. H. Simon, J. Lull, L. D. Jacobs, R. A. Rudick, D. L. Cookfair, R. M. Herndon, J. R. Richert, A. M. Salazar, J. Sheeder, D. Miller, et al. A longitudinal study of T1 hypointense lesions in relapsing MS: MSCRG trial of interferon {beta}-1a Neurology, July 25, 2000; 55(2): 185 - 192. [Abstract] [Full Text] [PDF]

				Y. Ge, R. I. Grossman, J. K. Udupa, L. Wei, L. J. Mannon, M. Polansky, and D. L. Kolson Brain Atrophy in Relapsing-Remitting Multiple Sclerosis and Secondary Progressive Multiple Sclerosis: Longitudinal Quantitative Analysis Radiology, March 1, 2000; 214(3): 665 - 670. [Abstract] [Full Text]

				J. H. Simon, L. D. Jacobs, M. K. Campion, R. A. Rudick, D. L. Cookfair, R. M. Herndon, J. R. Richert, A. M. Salazar, J. S. Fischer, D. E. Goodkin, et al. A longitudinal study of brain atrophy in relapsing multiple sclerosis Neurology, July 1, 1999; 53(1): 139 - 139. [Abstract] [Full Text]